Aging is a biological phenomenon in which the structure and function of organisms declining
with the increasing of age. It has become a major risk factor of human diseases, including …

Abstract Silent information regulator 1 (SIRT1) is a ubiquitously expressed protein and has
an intricate role in the pathology, progression, and treatment of several diseases. SIRT1 is a …

Sirtuin is an essential factor that delays cellular senescence and extends the organismal
lifespan through the regulation of diverse cellular processes. Suppression of cellular …

NAD+ has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and
maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded …

The 5′-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a natural
energy sensor in mammalian cells that plays a key role in cellular and systemic energy …

Eukaryotic cells compartmentalize their internal milieu in order to achieve specific reactions
in time and space. This organization in distinct compartments is essential to allow …

Ageing is a plastic process and can be successfully modulated by some biomedical
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …

Post-translational acetylation of lysine residues has emerged as a key regulatory
mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique …

Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

With the advent of next generation sequencing techniques a previously unknown world of
non-coding RNA molecules have been discovered. Non-coding RNA transcripts likely …