Advanced glycation end products (AGEs), the products of non-enzymatic browning reactions
between the active carbonyl groups of reducing sugars and the free amines of amino acids …

Twenty years have passed since Brownlee and colleagues proposed a single unifying
mechanism for diabetic complications, introducing a turning point in this field of research …

A peculiar role for oxidative stress in non-alcoholic fatty liver disease (NAFLD) and its
transition to the inflammatory complication non-alcoholic steatohepatitis (NASH), as well as …

The nonenzymatic adduction of malondialdehyde (MDA) to the protein amino groups leads
to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of …

Background N ε-carboxymethyllysine (CML) and N ε-carboxyethyllysine (CEL) are two
typical advanced glycation end products (AGEs) formed at the advanced stage of Maillard …

The receptor for advanced glycation end products (RAGE) is a member of the
immunoglobulin family that is overexpressed in several cancers. RAGE is highly expressed …

Simple Summary Diabetic people have an increased risk of developing several types of
cancers, particularly pancreatic cancer. The higher availability of glucose and/or lipids that …

Oxidative stress induced by neutrophils and hypoxia in COVID-19 pneumonia leads to
albumin modification. This may result in elevated levels of advanced oxidation protein …

Protein lipoxidation is a non-enzymatic post-translational modification that consists of the
covalent addition of reactive lipid species to proteins. This occurs under basal conditions but …

Carbonyl stress is a condition characterized by an increase in the steady-state levels of
reactive carbonyl species (RCS) that leads to accumulation of their irreversible covalent …