Abstract Structure and function are highly correlated in the vertebrate retina, a sensory tissue
that is organized into cell layers with microcircuits working in parallel and together to encode …

The melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs) are
a relatively recently discovered class of atypical ganglion cell photoreceptor. These ipRGCs …

Programmed cell death (PCD) is an evolutionarily conserved contributor to nervous system
development. In the vertebrate peripheral nervous system, PCD is the basis of the …

The concept that target tissues determine the survival of neurons has inspired much of the
thinking on neuronal development in vertebrates, not least because it is supported by …

In spite of the high metabolic cost of cellular production, the brain contains only a fraction of
the neurons generated during embryonic development. In the rodent cerebral cortex, a first …

Microglia play important roles in shaping the developing CNS, and at early stages they have
been proposed to regulate progenitor proliferation, differentiation, and neuronal survival …

Naturally occurring cell death is a fundamental developmental mechanism for regulating cell
numbers and sculpting developing organs. This is particularly true in the nervous system …

Introduction Direction-selective responses to visual cues depend upon precise connectivity
between inhibitory starburst amacrine cells (SACs) and direction-selective ganglion cells …

Spontaneous activity is a hallmark of developing neural systems. In the retina, spontaneous
activity comes in the form of retinal waves, comprised of three stages persisting from …

Retinal ganglion cells (RGCs) relay visual information from the eye to the brain. RGCs are
the first cell type generated during retinal neurogenesis. Loss of function of the transcription …