The rapidly spreading outbreak of COVID-19 disease is caused by the SARS-CoV-2 virus,
first reported in December 2019 in Wuhan, China. As of June 17, 2020, this virus has …

Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a
limited understanding of its clinical pathogenic spectrum of infection and disease …

Executive summary Tuberculosis can be treated, prevented, and cured. Rapid, sustained
declines in tuberculosis deaths in many countries during the past 50 years provide …

Most infections with Mycobacterium tuberculosis (Mtb) manifest as a clinically asymptomatic,
contained state, known as latent tuberculosis infection, that affects approximately one …

BACKGROUND The mammalian immune system is a remarkable sensory system for the
detection and neutralization of pathogens. History is replete with the devastating effects of …

Rationale: Contacts of patients with tuberculosis (TB) constitute an important target
population for preventive measures because they are at high risk of infection with …

Nearly 40 years have elapsed since the invention of the PCR, with its extremely sensitive
and specific ability to detect nucleic acids via in vitro enzyme-mediated amplification. In turn …

Tuberculosis (TB) is a leading cause of morbidity and mortality from a single infectious
agent, despite being preventable and curable. Early and accurate diagnosis of active TB is …

Mycobacterium tuberculosis complex (MTBC) refers to a group of mycobacteria
encompassing nine members of closely related species that causes tuberculosis in animals …

Millions of cases of tuberculosis (TB) go undiagnosed each year. Better diagnostic tools are
urgently needed. Biomarker-based or multiple marker biosignature-based tests, ideally …