Fungal secondary metabolism: regulation, function and drug discovery
NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …
Translating biosynthetic gene clusters into fungal armor and weaponry
NP Keller - Nature chemical biology, 2015 - nature.com
Filamentous fungi are renowned for the production of a diverse array of secondary
metabolites (SMs) where the genetic material required for synthesis of a SM is typically …
metabolites (SMs) where the genetic material required for synthesis of a SM is typically …
Fragment-based covalent ligand screening enables rapid discovery of inhibitors for the RBR E3 ubiquitin ligase HOIP
H Johansson, YC Isabella Tsai, K Fantom… - Journal of the …, 2019 - ACS Publications
Modification of proteins with polyubiquitin chains is a key regulatory mechanism to control
cellular behavior and alterations in the ubiquitin system are linked to many diseases. Linear …
cellular behavior and alterations in the ubiquitin system are linked to many diseases. Linear …
A call to arms: Mustering secondary metabolites for success and survival of an opportunistic pathogen
N Raffa, NP Keller - PLoS pathogens, 2019 - journals.plos.org
Aspergillus fumigatus is a ubiquitous saprophytic mold able to grow on a diversity of material
ranging from decayed organic matter in the environment to space station cupolas [1]. Yet this …
ranging from decayed organic matter in the environment to space station cupolas [1]. Yet this …
The Aspergilli and Their Mycotoxins: Metabolic Interactions With Plants and the Soil Biota
Species of the highly diverse fungal genus Aspergillus are well-known agricultural pests,
and, most importantly, producers of various mycotoxins threatening food safety worldwide …
and, most importantly, producers of various mycotoxins threatening food safety worldwide …
Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi
Secondary metabolites (SM) produced by fungi and bacteria have long been of exceptional
interest owing to their unique biomedical ramifications. The traditional discovery of new …
interest owing to their unique biomedical ramifications. The traditional discovery of new …
Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection
P Alves de Castro, C Figueiredo Pinzan… - Nature …, 2024 - nature.com
Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases
known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and …
known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and …
Secondary metabolite arsenal of an opportunistic pathogenic fungus
Aspergillus fumigatus is a versatile fungus able to successfully exploit diverse environments
from mammalian lungs to agricultural waste products. Among its many fitness attributes are …
from mammalian lungs to agricultural waste products. Among its many fitness attributes are …
The inconspicuous gatekeeper: endophytic Serendipita vermifera acts as extended plant protection barrier in the rhizosphere
D Sarkar, H Rovenich, G Jeena, S Nizam… - New …, 2019 - Wiley Online Library
In nature, beneficial and pathogenic fungi often simultaneously colonise plants. Despite
substantial efforts to understand the composition of natural plant− microbe communities, the …
substantial efforts to understand the composition of natural plant− microbe communities, the …
Using gene expression to study specialized metabolism—a practical guide
Plants produce a vast array of chemical compounds that we use as medicines and flavors,
but these compounds' biosynthetic pathways are still poorly understood. This paucity …
but these compounds' biosynthetic pathways are still poorly understood. This paucity …