Fungal secondary metabolism: regulation, function and drug discovery

NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

Translating biosynthetic gene clusters into fungal armor and weaponry

NP Keller - Nature chemical biology, 2015 - nature.com
Filamentous fungi are renowned for the production of a diverse array of secondary
metabolites (SMs) where the genetic material required for synthesis of a SM is typically …

Fragment-based covalent ligand screening enables rapid discovery of inhibitors for the RBR E3 ubiquitin ligase HOIP

H Johansson, YC Isabella Tsai, K Fantom… - Journal of the …, 2019 - ACS Publications
Modification of proteins with polyubiquitin chains is a key regulatory mechanism to control
cellular behavior and alterations in the ubiquitin system are linked to many diseases. Linear …

A call to arms: Mustering secondary metabolites for success and survival of an opportunistic pathogen

N Raffa, NP Keller - PLoS pathogens, 2019 - journals.plos.org
Aspergillus fumigatus is a ubiquitous saprophytic mold able to grow on a diversity of material
ranging from decayed organic matter in the environment to space station cupolas [1]. Yet this …

The Aspergilli and Their Mycotoxins: Metabolic Interactions With Plants and the Soil Biota

WP Pfliegler, I Pócsi, Z Győri, T Pusztahelyi - Frontiers in microbiology, 2020 - frontiersin.org
Species of the highly diverse fungal genus Aspergillus are well-known agricultural pests,
and, most importantly, producers of various mycotoxins threatening food safety worldwide …

Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi

PN Tran, MR Yen, CY Chiang, HC Lin… - Applied microbiology and …, 2019 - Springer
Secondary metabolites (SM) produced by fungi and bacteria have long been of exceptional
interest owing to their unique biomedical ramifications. The traditional discovery of new …

Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection

P Alves de Castro, C Figueiredo Pinzan… - Nature …, 2024 - nature.com
Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases
known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and …

Secondary metabolite arsenal of an opportunistic pathogenic fungus

E Bignell, TC Cairns… - … of the Royal …, 2016 - royalsocietypublishing.org
Aspergillus fumigatus is a versatile fungus able to successfully exploit diverse environments
from mammalian lungs to agricultural waste products. Among its many fitness attributes are …

The inconspicuous gatekeeper: endophytic Serendipita vermifera acts as extended plant protection barrier in the rhizosphere

D Sarkar, H Rovenich, G Jeena, S Nizam… - New …, 2019 - Wiley Online Library
In nature, beneficial and pathogenic fungi often simultaneously colonise plants. Despite
substantial efforts to understand the composition of natural plant− microbe communities, the …

Using gene expression to study specialized metabolism—a practical guide

R Delli-Ponti, D Shivhare, M Mutwil - Frontiers in Plant Science, 2021 - frontiersin.org
Plants produce a vast array of chemical compounds that we use as medicines and flavors,
but these compounds' biosynthetic pathways are still poorly understood. This paucity …