Renal cell carcinoma (RCC) is the seventh most common cancer in men and the ninth most
common cancer in women worldwide. There is plenty of evidence about the role of the …

Immune checkpoint blockade is a compelling approach in tumor immunotherapy. Blocking
inhibitory pathways in T cells has demonstrated clinical efficacy in different types of cancer …

Immune checkpoints (ICs) have pivotal roles in regulating immune responses. The inhibitory
ICs in the tumor microenvironment (TME) have been implicated in the immune evasion of …

Purpose: CD70 is a costimulatory molecule known to activate CD27-expressing T cells.
CD27–CD70 interaction leads to the release of soluble CD27 (sCD27). Clear-cell renal cell …

HLA-G is known to modulate the immune system activity in tissues where physiological
immune-tolerance is necessary (ie, maternal-fetal interface, thymus, and cornea). However …

Cancer immunotherapy strategies are based on the utilization of immune checkpoint
inhibitors to instigate an antitumor immune response. The efficacy of immune checkpoint …

The prognosis for advanced clear cell renal cell carcinoma (ccRCC) is not satisfactory, even
though its treatment has evolved rapidly over the past 20 years. Systemic ccRCC treatment …

Objectives Tumor necrosis receptor super family (TNFRSF) plays an important role in
regulating the function of CD8+ T cells. In this study, we explored the clinical significance …

Recently, cancer immunotherapy has revolutionized cancer treatment. Various forms of
immunotherapy have a manageable safety profile and result in prolongation of overall …

B7 homolog 3 (B7‐H3) plays an important role in tumor biology, but the molecular
mechanism underlying the role of B7‐H3 in tumor metastasis remains unclear. In this article …