The human gut contains trillions of symbiotic bacteria that play a key role in programming
different aspects of host physiology in health and disease. Psychotropic medications act on …

The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …

Background Identifying new antifungals for cryptococcal meningitis is a priority given the
inadequacy of current therapy. Sertraline has previously shown in vitro and in vivo activity …

The morbidity and mortality caused by invasive fungal infections are increasing across the
globe due to developments in transplant surgery, the use of immunosuppressive agents …

Moving towards a systems psychiatry paradigm embraces the inherent complex interactions
across all levels from micro to macro and necessitates an integrated approach to treatment …

Immunodepression, whether due to HIV infection or organ transplantation, has increased
human vulnerability to fungal infections. These conditions have created an optimal …

Abstract Purpose of the Review Cryptococcal disease is most often thought of in the context
of HIV infection. Much of our knowledge of the disease originates from its management in …

The prevalence and increasing incidence of fungal infections globally is a significant
worldwide health problem. Cryptococcosis, primarily caused by the pathogenic yeast …

Background Cryptococcal meningitis has fatality rates of 40%‐70%, resulting in 200 000
deaths each year. The best outcomes are achieved with amphotericin combined with …

Fungal infections caused by Cryptococcus spp. pose a threat to health, especially in
immunocompromised individuals. The available arsenal of drugs against cryptococcosis is …