The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers
in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the …

A variety of stimuli utilize an increase of cytosolic free Ca2+ concentration as a second
messenger to transmit signals, through Ca2+ release from the endoplasmic reticulum or …

Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and
damaging pathways in different tissues. In addition, mitochondria are an important target of …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Heart diseases due to myocardial ischemia, such as myocardial infarction or ischemic heart
failure, are major causes of death in developed countries, and their number is unfortunately …

This paper reviews new drug targets in the treatment of depression and new drug
candidates to treat depression. Depression is characterized by aberrations in six intertwined …

Myocardial injury induces significant changes in ventricular structure and function at both the
cellular and anatomic level, leading to ventricular remodeling and subsequent heart failure …

Recently, coordinatively saturated and substitutionally inert Ru (II) complexes have been
investigated as anticancer agents. Herein a cyclometalated Ru (II) complex,[Ru …

Mitochondrial dysfunction is one of the fundamental causes of ischemia reperfusion (I/R)
damage. I/R refers to the paradoxical progression of cellular dysfunction and death that …