Interferon (IFN)-mediated antiviral responses are central to host defence against viral
infection. Despite the existence of at least 20 IFNs, there are only three known cell surface …

Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively,
they are highly effective at resisting and controlling pathogens. In this review, we begin by …

The type I interferon response protects cells against invading viral pathogens. The cellular
factors that mediate this defence are the products of interferon-stimulated genes (ISGs) …

During the last decades, the pleiotropic antitumor functions exerted by type I interferons
(IFNs) have become universally acknowledged, especially their role in mediating …

While type I interferons (IFNs) are universally acknowledged for their antiviral and
immunostimulatory functions, there is increasing appreciation of the detrimental effects of …

The type I interferons (IFNs) are pleiotropic cytokines that regulate many different cellular
functions. The major signaling pathway activated by type I IFNs involves sequential …

Type I interferons (IFNs) form a network of homologous cytokines that bind to a shared,
heterodimeric cell surface receptor and engage signaling pathways that activate innate and …

Despite activating similar signaling cascades, the type I and type III interferons (IFNs) differ
in their ability to antagonize virus replication. However, it is not clear whether these …

Interferons (IFNs) are cytokines that possess potent anti-viral and immunoregulatory
activities. In contrast, their potential role (s) in anti-bacterial defense and neutrophil …

During most viral infections, the immediate host response is characterized by an induction of
type I IFN. These cytokines have various biological activities, including anti‐viral, anti …