Anticancer thiosemicarbazones: chemical properties, interaction with iron metabolism, and resistance development
FS PapeVeronika, A EnyedyÉva… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: During the past decades, thiosemicarbazones were clinically developed for a
variety of diseases, including tuberculosis, viral infections, malaria, and cancer. With regard …
variety of diseases, including tuberculosis, viral infections, malaria, and cancer. With regard …
Copper-catalyzed glutathione oxidation is accelerated by the anticancer thiosemicarbazone Dp44mT and further boosted at lower pH
E Falcone, AG Ritacca, S Hager… - Journal of the …, 2022 - ACS Publications
Glutathione (GSH) is the most abundant thiol in mammalian cells and plays a crucial role in
maintaining redox cellular homeostasis. The thiols of two GSH molecules can be oxidized to …
maintaining redox cellular homeostasis. The thiols of two GSH molecules can be oxidized to …
New water-soluble copper (II) complexes with morpholine–thiosemicarbazone hybrids: Insights into the anticancer and antibacterial mode of action
K Ohui, E Afanasenko, F Bacher, RLX Ting… - Journal of medicinal …, 2018 - ACS Publications
Six morpholine-(iso) thiosemicarbazone hybrids HL 1–HL 6 and their Cu (II) complexes with
good-to-moderate solubility and stability in water were synthesized and characterized. Cu …
good-to-moderate solubility and stability in water were synthesized and characterized. Cu …
The coordination modes of (thio) semicarbazone copper (II) complexes strongly modulate the solution chemical properties and mechanism of anticancer activity
Thiosemicarbazones are promising candidates for anticancer therapy and their mechanism
of action is often linked to their metal chelating ability. In this study, five (thio) …
of action is often linked to their metal chelating ability. In this study, five (thio) …
High copper complex stability and slow reduction kinetics as key parameters for improved activity, paraptosis induction, and impact on drug-resistant cells of …
Aims: Due to their significant biological activity, thiosemicarbazones (TSCs) are promising
candidates for anticancer therapy. In part, the efficacy of TSCs is linked to their ability to …
candidates for anticancer therapy. In part, the efficacy of TSCs is linked to their ability to …
Synthesis, characterization, anticancer, pharmacokinetics and molecular docking investigation of N (3)-alkyl incorporated-3-acetyl-4-hydroxycoumarin …
Abstract Coumarin based thiosemicarbazones (TSC),(E)-2-(1-(4‑hydroxy-2-oxo-2H-chromen-
3-yl) ethylidene)-N-methylhydrazine-1-carbothioamide (HACmMeTsc)(3),(E)-N-ethyl-2-(1-(4 …
3-yl) ethylidene)-N-methylhydrazine-1-carbothioamide (HACmMeTsc)(3),(E)-N-ethyl-2-(1-(4 …
Triapine analogues and their copper (II) complexes: Synthesis, characterization, solution speciation, redox activity, cytotoxicity, and mR2 RNR inhibition
I Besleaga, I Stepanenko, TV Petrasheuskaya… - Inorganic …, 2021 - ACS Publications
Three new thiosemicarbazones (TSCs) HL 1–HL 3 as triapine analogues bearing a redox-
active phenolic moiety at the terminal nitrogen atom were prepared. Reactions of HL 1–HL 3 …
active phenolic moiety at the terminal nitrogen atom were prepared. Reactions of HL 1–HL 3 …
[HTML][HTML] Half-sandwich arene ruthenium (II) thiosemicarbazone complexes: evaluation of anticancer effect on primary and metastatic ovarian cancer cell lines
S Guler, HA Kayali, EO Sadan, B Sen… - Frontiers in …, 2022 - frontiersin.org
In this study, we describe the synthesis, characterization and antiproliferative activity of three
organo-ruthenium (II) half-sandwich complexes [RuCl (η6-p-cym)(N, SL)] Cl (I, II, and III). To …
organo-ruthenium (II) half-sandwich complexes [RuCl (η6-p-cym)(N, SL)] Cl (I, II, and III). To …
Inhibitory properties of aromatic thiosemicarbazones on mushroom tyrosinase: Synthesis, kinetic studies, molecular docking and effectiveness in melanogenesis …
K Hałdys, W Goldeman, M Jewgiński, E Wolińska… - Bioorganic …, 2018 - Elsevier
The group of 19 thiosemicarbazones (TSCs) were synthesized and its inhibitory activity
toward mushroom tyrosinase and ability to inhibition of melanogenesis in B16 cells were …
toward mushroom tyrosinase and ability to inhibition of melanogenesis in B16 cells were …
Synthesis, antiproliferative activity and mechanism of copper (II)-thiosemicarbazone complexes as potential anticancer and antimicrobial agents
J Qi, X Wang, T Liu, M Kandawa-Schulz… - Journal of …, 2020 - Taylor & Francis
Malignant tumors have become one of the challenges to global human health today, and the
development of new drugs has become a research hotspot for tumor treatment. In order to …
development of new drugs has become a research hotspot for tumor treatment. In order to …