An updated review of lysophosphatidylcholine metabolism in human diseases
SH Law, ML Chan, GK Marathe, F Parveen… - International journal of …, 2019 - mdpi.com
Lysophosphatidylcholine (LPC) is increasingly recognized as a key marker/factor positively
associated with cardiovascular and neurodegenerative diseases. However, findings from …
associated with cardiovascular and neurodegenerative diseases. However, findings from …
Cholesterol metabolism in neurons and astrocytes
FW Pfrieger, N Ungerer - Progress in lipid research, 2011 - Elsevier
Cells in the mammalian body must accurately maintain their content of cholesterol, which is
an essential membrane component and precursor for vital signalling molecules. Outside the …
an essential membrane component and precursor for vital signalling molecules. Outside the …
Abnormal brain cholesterol homeostasis in Alzheimer's disease—a targeted metabolomic and transcriptomic study
VR Varma, H Büşra Lüleci, AM Oommen… - npj Aging and …, 2021 - nature.com
The role of brain cholesterol metabolism in Alzheimer's disease (AD) remains unclear.
Peripheral and brain cholesterol levels are largely independent due to the impermeability of …
Peripheral and brain cholesterol levels are largely independent due to the impermeability of …
HDL and cholesterol handling in the brain
C Vitali, CL Wellington, L Calabresi - Cardiovascular research, 2014 - academic.oup.com
Cholesterol is an essential component of both the peripheral nervous system and central
nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes …
nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes …
The cell biology of APOE in the brain
IA Windham, S Cohen - Trends in Cell Biology, 2023 - cell.com
Apolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE
is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other …
is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other …
Cellular cholesterol homeostasis and Alzheimer's disease: thematic review series: ApoE and lipid homeostasis in Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia in older adults. Currently,
there is no cure for AD. The hallmark of AD is the accumulation of extracellular amyloid …
there is no cure for AD. The hallmark of AD is the accumulation of extracellular amyloid …
Lipoproteins in the central nervous system: from biology to pathobiology
AC Raulin, YA Martens, G Bu - Annual review of biochemistry, 2022 - annualreviews.org
The brain, as one of the most lipid-rich organs, heavily relies on lipid transport and
distribution to maintain homeostasis and neuronal function. Lipid transport mediated by …
distribution to maintain homeostasis and neuronal function. Lipid transport mediated by …
Lecithin: cholesterol acyltransferase: old friend or foe in atherosclerosis?
S Kunnen, M Van Eck - Journal of lipid research, 2012 - ASBMB
Lecithin: cholesterol acyltransferase (LCAT) is a key enzyme that catalyzes the esterification
of free cholesterol in plasma lipoproteins and plays a critical role in high-density lipoprotein …
of free cholesterol in plasma lipoproteins and plays a critical role in high-density lipoprotein …
Next-generation sequencing-based small RNA profiling of cerebrospinal fluid exosomes
Y Yagi, T Ohkubo, H Kawaji, A Machida, H Miyata… - Neuroscience …, 2017 - Elsevier
MicroRNAs (miRNAs), particularly those found in human body fluids, have been suggested
as potential biomarkers. Among various body fluids, the cerebrospinal fluid (CSF) shows …
as potential biomarkers. Among various body fluids, the cerebrospinal fluid (CSF) shows …
Formation and function of apolipoprotein E-containing lipoproteins in the nervous system
JE Vance, H Hayashi - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2010 - Elsevier
The strongest known genetic risk factor for the development of late-onset Alzheimer disease
is inheritance of the apolipoprotein (apo) E4 (ε4 allele) although the mechanisms underlying …
is inheritance of the apolipoprotein (apo) E4 (ε4 allele) although the mechanisms underlying …