Lysophosphatidylcholine (LPC) is increasingly recognized as a key marker/factor positively
associated with cardiovascular and neurodegenerative diseases. However, findings from …

Cells in the mammalian body must accurately maintain their content of cholesterol, which is
an essential membrane component and precursor for vital signalling molecules. Outside the …

The role of brain cholesterol metabolism in Alzheimer's disease (AD) remains unclear.
Peripheral and brain cholesterol levels are largely independent due to the impermeability of …

Cholesterol is an essential component of both the peripheral nervous system and central
nervous system (CNS) of mammals. Brain cholesterol is synthesized in situ by astrocytes …

Apolipoprotein E (APOE) traffics lipids in the central nervous system. The E4 variant of APOE
is a major genetic risk factor for Alzheimer's disease (AD) and a multitude of other …

Alzheimer's disease (AD) is the most common form of dementia in older adults. Currently,
there is no cure for AD. The hallmark of AD is the accumulation of extracellular amyloid …

The brain, as one of the most lipid-rich organs, heavily relies on lipid transport and
distribution to maintain homeostasis and neuronal function. Lipid transport mediated by …

Lecithin: cholesterol acyltransferase (LCAT) is a key enzyme that catalyzes the esterification
of free cholesterol in plasma lipoproteins and plays a critical role in high-density lipoprotein …

MicroRNAs (miRNAs), particularly those found in human body fluids, have been suggested
as potential biomarkers. Among various body fluids, the cerebrospinal fluid (CSF) shows …

The strongest known genetic risk factor for the development of late-onset Alzheimer disease
is inheritance of the apolipoprotein (apo) E4 (ε4 allele) although the mechanisms underlying …