Aging is a natural aspect of mammalian life. Although cellular mortality is inevitable, various
diseases can hasten the aging process, resulting in abnormal or premature senescence. As …

CGG repeat expansions in the FMR1 5'UTR cause the neurodegenerative disease Fragile X-
associated tremor/ataxia syndrome (FXTAS). These repeats form stable RNA secondary …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
dopaminergic neuronal cell death. Emerging evidence suggest exosomes as a crucial …

Mitochondria are the energy-producing organelles of mammalian cells with critical
involvement in metabolism and signaling. Studying their regulation in pathological …

Tumor microenvironment (TME) of solid tumors including breast cancer is complex and
contains a distinct cytokine pattern including TNF-α, which determines the progression and …

Background Women who carry a premutation allele of the FMR1 gene are at increased
vulnerability to an array of age-related symptoms and disorders, including age-related …

MicroRNAs (miRNAs) are small non-coding RNAs that play an important role by controlling
gene expression in the cytoplasm in almost all biological pathways. Recently, scientists …

Abnormal trinucleotide expansions cause rare disorders that compromise quality of life and,
in some cases, lifespan. In particular, the expansions of the CGG-repeats stretch at the 5' …

Purpose: The Fragile X Messenger Ribonucleoprotein-1 (FMR1) premutation (FXpm) is a
genetic variant that is common in the general population and is associated with health …

Parkinson's disease (PD) is a chronic neurodegenerative disease characterized by
progressive loss of dopamine‐producing neurons from the substantia nigra region of the …