Anti-cancer chalcones: Structural and molecular target perspectives
Abstract Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold remained a fascination
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …
among researchers in the 21st century due to its simple chemistry, ease of synthesis and a …
The therapeutic voyage of pyrazole and its analogs: a review
Pyrazole, a five membered heteroaromatic ring with two nitrogen atoms is of immense
significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic …
significance. Presence of this nucleus in the pharmacological agents of diverse therapeutic …
Chalcone scaffolds as anti-infective agents: Structural and molecular target perspectives
In recent years, widespread outbreak of numerous infectious diseases across the globe has
created havoc among the population. Particularly, the inhabitants of tropical and sub-tropical …
created havoc among the population. Particularly, the inhabitants of tropical and sub-tropical …
Roles of histone deacetylases and inhibitors in anticancer therapy
Histones are the main structural proteins of eukaryotic chromatin. Histone acetylation/
deacetylation are the epigenetic mechanisms of the regulation of gene expression and are …
deacetylation are the epigenetic mechanisms of the regulation of gene expression and are …
Therapeutic potential of chalcones as cardiovascular agents
DK Mahapatra, SK Bharti - Life sciences, 2016 - Elsevier
Cardiovascular diseases are the leading cause of death affecting 17.3 million people across
the globe and are estimated to affect 23.3 million people by year 2030. In recent years …
the globe and are estimated to affect 23.3 million people by year 2030. In recent years …
Novel piperazine–chalcone hybrids and related pyrazoline analogues targeting VEGFR-2 kinase; design, synthesis, molecular docking studies, and anticancer …
MF Ahmed, EY Santali, R El-Haggar - Journal of enzyme inhibition …, 2021 - Taylor & Francis
New piperazine–chalcone hybrids and related pyrazoline derivatives have been designed
and synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) …
and synthesised as potential vascular endothelial growth factor receptor-2 (VEGFR-2) …
Nickel-catalyzed reductive cross-coupling of heteroaryl chlorides and aryl chlorides
We report a nickel-catalyzed cross-electrophile coupling reaction of aryl chlorides and
heteroaryl chlorides enabled by a synergistic combination consisting of halide effects and …
heteroaryl chlorides enabled by a synergistic combination consisting of halide effects and …
Design and synthesis of novel quinazolinone-pyrazole derivatives as potential α-glucosidase inhibitors: Structure-activity relationship, molecular modeling and kinetic …
In this study, a new series of quinazolinone-pyrazole hybrids were designed, synthesized
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …
and screened for their α-glucosidase inhibitory activity. The results of the in vitro screening …
Catalytic Synthesis of 1,2,4,5‐Tetrasubstituted 1H‐Imidazole Derivatives: State of the Art
R Rossi, G Angelici, G Casotti… - … Synthesis & Catalysis, 2019 - Wiley Online Library
Tetrasubstituted 1H‐imidazoles are a large family of heteroarene derivatives that are known
to include natural products isolated from marine sponges and synthetic compounds …
to include natural products isolated from marine sponges and synthetic compounds …
Synthesis and anti-proliferative activity of fluoro-substituted chalcones
A series of novel fluoro-substituted chalcone derivatives have been synthesized. All
synthesized compounds were characterized by 1 H nuclear magnetic resonance (NMR), 13 …
synthesized compounds were characterized by 1 H nuclear magnetic resonance (NMR), 13 …