Neutrophil extracellular traps in homeostasis and disease

H Wang, SJ Kim, Y Lei, S Wang, H Wang… - … and Targeted Therapy, 2024 - nature.com
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are
renowned for their propensity to expel decondensed chromatin embedded with inflammatory …

A narrative review: the role of NETs in acute respiratory distress syndrome/acute lung injury

X Zhou, J Jin, T Lv, Y Song - International Journal of Molecular Sciences, 2024 - mdpi.com
Nowadays, acute respiratory distress syndrome (ARDS) still has a high mortality rate, and
the alleviation and treatment of ARDS remains a major research focus. There are various …

A mimetic peptide of ACE2 protects against SARS-CoV-2 infection and decreases pulmonary inflammation related to COVID-19

EH Oliveira, AC Monteleone-Cassiano, L Tavares… - Antiviral Research, 2024 - Elsevier
Since human angiotensin-converting enzyme 2 (ACE2) serves as a primary receptor for
SARS-CoV-2, characterizing ACE2 regions that allow SARS-CoV-2 to enter human cells is …

The multi-herbal decoction SH003 alleviates LPS-induced acute lung injury by targeting inflammasome and extracellular traps in neutrophils

HI Kim, Y Han, MH Kim, M Boo, KJ Cho, HL Kim, IS Lee… - Phytomedicine, 2024 - Elsevier
Background Acute lung injury (ALI) is a devastating condition caused by sepsis, pneumonia,
trauma, and more recently, COVID-19. SH003, an herbal formula consisted of Astragalus …

Bulk and single-cell RNA sequencing analysis with 101 machine learning combinations reveal neutrophil extracellular trap involvement in hepatic ischemia …

M Xie, Z He, B Bin, N Wen, J Wu, X Cai… - International …, 2024 - Elsevier
Background Hepatic ischaemia–reperfusion injury (HIRI) is a major clinical concern during
the perioperative period and is closely associated with early allograft dysfunction (EAD) …

Hexamerization: explaining the original sin of IgG-mediated complement activation in acute lung injury

HS Kulkarni - The Journal of Clinical Investigation, 2024 - Am Soc Clin Investig
Although antibody-mediated lung damage is a major factor in transfusion-related acute lung
injury (ALI), autoimmune lung disease (for example, coatomer subunit α [COPA] syndrome) …

Phytoconstituents as modulator of inflammatory pathways for COVID‐19: A comprehensive review and recommendations

P Gupta, K Dev, G Kaur - Phytotherapy Research, 2024 - Wiley Online Library
SARS‐CoV‐2 infection causes disruptions in inflammatory pathways, which fundamentally
contribute to COVID‐19 pathophysiology. The present review critically evaluates the gaps in …

The complement system: A key player in the host response to infections

A Jayaraman, S Walachowski… - European Journal of …, 2024 - Wiley Online Library
Infections are one of the most significant healthcare and economic burdens across the world
as underscored by the recent coronavirus pandemic. Moreover, with the increasing …

Neutrophil Extracellular Traps in Cardiovascular and Aortic Disease: A Narrative Review on Molecular Mechanisms and Therapeutic Targeting

N Ibrahim, W Eilenberg, C Neumayer… - International Journal of …, 2024 - mdpi.com
Neutrophil extracellular traps (NETs), composed of DNA, histones, and antimicrobial
proteins, are released by neutrophils in response to pathogens but are also recognized for …

Crosstalk between neutrophil extracellular traps and immune regulation: insights into pathobiology and therapeutic implications of transfusion-related acute lung injury

Y Liu, R Wang, C Song, S Ding, Y Zuo, K Yi… - Frontiers in …, 2023 - frontiersin.org
Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated
death, occurring during or within 6 hours after transfusion. Reports indicate that TRALI can …