In the majority of patients multiple sclerosis starts with a relapsing remitting course (RRMS),
which may at later times transform into secondary progressive disease (SPMS). In a minority …

Multiple sclerosis (MS) is traditionally seen as an inflammatory demyelinating disease,
characterized by the formation of focal demyelinated plaques in the white matter of the …

Background: Multiple sclerosis (MS) is a complex disease with new drugs becoming
available in the past years. There is a need for a reference tool compiling current data to aid …

Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis
pathology, only partially explain the patient's clinical deficits. We thus analysed global brain …

Multiple sclerosis can follow very different patterns of evolution and variable rates of
disability accumulation. This raises the issue whether it represents one or several distinct …

The primary progressive form of multiple sclerosis is characterized by accrual of
neurological dysfunction from disease onset without remission and it is still a matter of …

The clinical features of relapses and progression largely define multiple sclerosis
phenotypes. A relapsing course is followed by chronic progression in some 80% of cases …

Background: It is unclear if all patients with relapsing–remitting multiple sclerosis (RRMS)
ultimately develop progressive MS. Onset of progressive disease course seems to be age …

Objective: To assess cortical gray matter (GM) changes in MS and establish their relevance
to clinical disability and to inflammatory changes of white matter (WM) in patients with the …

The secondary progressive phase of multiple sclerosis (MS), which is characterised by a
steady accrual of fixed disability after an initial relapsing remitting course, is not clearly …