Retinoblastoma (Rb) is the most common primary intraocular malignancy of childhood, but
an uncommon paediatric cancer, with a constant incidence worldwide of 1: 15,000–1 …

Retinoblastoma is lethal by metastasis if left untreated, so the primary goal of therapy is to
preserve life, with ocular survival, visual preservation and quality of life as secondary aims …

Owing to the variety and complexity of ocular diseases and the natural ocular barriers, drug
therapy for ocular diseases has significant limitations, such as poor drug targeting to the site …

Retinoblastoma (RB) is a pediatric retinal tumor that overexpresses the ganglioside GD2.
Although it is treatable in patients with early diagnosis, patients may lose one or two eyes …

Retinoblastoma is a retinal cancer that is initiated in response to biallelic loss of RB1 in
almost all cases, together with other genetic/epigenetic changes culminating in the …

Abstract Intra-arterial chemotherapy (IAC), also known as superselective ophthalmic artery
chemotherapy or chemosurgery, is currently widely accepted as one of the primary treatment …

Background Survivors of heritable retinoblastoma carry a high risk to develop second
cancers. Eye‐preserving radiotherapy raises this risk, while the impact of chemotherapy …

Quercetin is a natural flavonol antioxidant found in various plant sources and food samples.
It is well known for its notable curative effects on the treatment of ophthalmic diseases due to …

Retinoblastoma is a pediatric solid tumor of the retina activated upon homozygous
inactivation of the tumor suppressor RB1. VCN-01 is an oncolytic adenovirus designed to …

Purpose The introduction of intra-arterial chemotherapy (IAC) as salvage treatment has
improved the prognosis for eye conservation in group D retinoblastoma. The aim of this …