Regulation and function of AMPK in physiology and diseases

SM Jeon - Experimental & molecular medicine, 2016 - nature.com
adenosine monophosphate (AMP)-activated protein kinase (AMPK) is an evolutionarily
conserved serine/threonine kinase that was originally identified as the key player in …

[HTML][HTML] Exercise, GLUT4, and skeletal muscle glucose uptake

EA Richter, M Hargreaves - Physiological reviews, 2013 - journals.physiology.org
Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …

Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency

B Joseph, D Jini - Asian pacific journal of tropical disease, 2013 - Elsevier
Diabetes mellitus is among the most common disorder in developed and developing
countries, and the disease is increasing rapidly in most parts of the world. It has been …

AMPK in health and disease

GR Steinberg, BE Kemp - Physiological reviews, 2009 - journals.physiology.org
The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

S Jäger, C Handschin, J St.-Pierre… - Proceedings of the …, 2007 - National Acad Sciences
Activation of AMP-activated kinase (AMPK) in skeletal muscle increases glucose uptake,
fatty acid oxidation, and mitochondrial biogenesis by increasing gene expression in these …

AMPK, metabolism, and vascular function

C Rodríguez, M Muñoz, C Contreras… - The FEBS …, 2021 - Wiley Online Library
Adenosine monophosphate‐activated protein kinase (AMPK) is a cellular energy sensor
activated during energy stress that plays a key role in maintaining energy homeostasis. This …

AMP-activated protein kinase in metabolic control and insulin signaling

MC Towler, DG Hardie - Circulation research, 2007 - Am Heart Assoc
The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status
that is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP: ATP …

The AMP-activated protein kinase pathway–new players upstream and downstream

DG Hardie - Journal of cell science, 2004 - journals.biologists.com
The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy status.
Whenever the cellular ATP: ADP ratio falls, owing to a stress that inhibits ATP production or …

[PDF][PDF] Physical activity/exercise and type 2 diabetes

RJ Sigal, GP Kenny, DH Wasserman… - Diabetes …, 2004 - paulogentil.com
For decades, exercise has been consid-ered a cornerstone of diabetes management, along
with diet and medication. However, high-quality evidence on the importance of exercise and …

AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling

DR Bolster, SJ Crozier, SR Kimball… - Journal of Biological …, 2002 - ASBMB
AMP-activated protein kinase (AMPK) is viewed as an energy sensor that acts to modulate
glucose uptake and fatty acid oxidation in skeletal muscle. Given that protein synthesis is a …