Structure and function of cationic and ionizable lipids for nucleic acid delivery
Hereditary genetic diseases, cancer, and infectious diseases are affecting global health and
become major health issues, but the treatment development remains challenging. Gene …
become major health issues, but the treatment development remains challenging. Gene …
Ocular drug delivery to the retina: current innovations and future perspectives
HM Kim, SJ Woo - Pharmaceutics, 2021 - mdpi.com
Treatment options for retinal diseases, such as neovascular age-related macular
degeneration, diabetic retinopathy, and retinal vascular disorders, have markedly expanded …
degeneration, diabetic retinopathy, and retinal vascular disorders, have markedly expanded …
Programmable and multifunctional DNA‐based materials for biomedical applications
DNA encodes the genetic information; recently, it has also become a key player in material
science. Given the specific Watson–Crick base‐pairing interactions between only four types …
science. Given the specific Watson–Crick base‐pairing interactions between only four types …
Recent advances of metal-based nanoparticles in nucleic acid delivery for therapeutic applications
AR Sharma, YH Lee, A Bat-Ulzii… - Journal of …, 2022 - Springer
Recent efforts in designing nanomaterials to deliver potential therapeutics to the targeted
site are overwhelming and palpable. Engineering nanomaterials to deliver biological …
site are overwhelming and palpable. Engineering nanomaterials to deliver biological …
Circulating exosomal microRNA‐96 promotes cell proliferation, migration and drug resistance by targeting LMO7
H Wu, J Zhou, S Mei, D Wu, Z Mu… - Journal of cellular …, 2017 - Wiley Online Library
Detection and treatment of lung cancer still remain a clinical challenge. This study aims to
validate exosomal microRNA‐96 (miR‐96) as a serum biomarker for lung cancer and …
validate exosomal microRNA‐96 (miR‐96) as a serum biomarker for lung cancer and …
Therapy approaches for Stargardt disease
E Piotter, ME McClements, RE MacLaren - Biomolecules, 2021 - mdpi.com
Despite being the most prevalent cause of inherited blindness in children, Stargardt disease
is yet to achieve the same clinical trial success as has been achieved for other inherited …
is yet to achieve the same clinical trial success as has been achieved for other inherited …
Hyaluronic-acid-modified lipid-polymer hybrid nanoparticles as an efficient ocular delivery platform for moxifloxacin hydrochloride
D Liu, Y Lian, Q Fang, L Liu, J Zhang, J Li - International journal of …, 2018 - Elsevier
To improve the ocular bioavailability of the strongly hydrophilic moxifloxacin hydrochloride,
hyaluronic-acid-modified lipid-polymer hybrid nanoparticles (HA-LCS-NPs) were designed …
hyaluronic-acid-modified lipid-polymer hybrid nanoparticles (HA-LCS-NPs) were designed …
Effective gene therapy of Stargardt disease with PEG-ECO/pGRK1-ABCA4-S/MAR nanoparticles
Stargardt disease (STGD) is the most common form of inherited retinal genetic disorders and
is often caused by mutations in ABCA4. Gene therapy has the promise to effectively treat …
is often caused by mutations in ABCA4. Gene therapy has the promise to effectively treat …
Nanoparticulate drug delivery to the retina
Retinal diseases, such as age-related macular degeneration and diabetic retinopathy, are
the leading causes of blindness worldwide. The mainstay of treatment for these blinding …
the leading causes of blindness worldwide. The mainstay of treatment for these blinding …
Ocular drug delivery-new strategies for targeting anterior and posterior segments of the eye
The ocular delivery of drugs encounters several limitations because of the dynamic and
static barriers of the human's eye anatomy and physiology. The poor bioavailability of drugs …
static barriers of the human's eye anatomy and physiology. The poor bioavailability of drugs …