Structure and function of cationic and ionizable lipids for nucleic acid delivery

D Sun, ZR Lu - Pharmaceutical Research, 2023 - Springer
Hereditary genetic diseases, cancer, and infectious diseases are affecting global health and
become major health issues, but the treatment development remains challenging. Gene …

Ocular drug delivery to the retina: current innovations and future perspectives

HM Kim, SJ Woo - Pharmaceutics, 2021 - mdpi.com
Treatment options for retinal diseases, such as neovascular age-related macular
degeneration, diabetic retinopathy, and retinal vascular disorders, have markedly expanded …

Programmable and multifunctional DNA‐based materials for biomedical applications

Y Zhang, J Tu, D Wang, H Zhu, SK Maity… - Advanced …, 2018 - Wiley Online Library
DNA encodes the genetic information; recently, it has also become a key player in material
science. Given the specific Watson–Crick base‐pairing interactions between only four types …

Recent advances of metal-based nanoparticles in nucleic acid delivery for therapeutic applications

AR Sharma, YH Lee, A Bat-Ulzii… - Journal of …, 2022 - Springer
Recent efforts in designing nanomaterials to deliver potential therapeutics to the targeted
site are overwhelming and palpable. Engineering nanomaterials to deliver biological …

Circulating exosomal microRNA‐96 promotes cell proliferation, migration and drug resistance by targeting LMO7

H Wu, J Zhou, S Mei, D Wu, Z Mu… - Journal of cellular …, 2017 - Wiley Online Library
Detection and treatment of lung cancer still remain a clinical challenge. This study aims to
validate exosomal microRNA‐96 (miR‐96) as a serum biomarker for lung cancer and …

Therapy approaches for Stargardt disease

E Piotter, ME McClements, RE MacLaren - Biomolecules, 2021 - mdpi.com
Despite being the most prevalent cause of inherited blindness in children, Stargardt disease
is yet to achieve the same clinical trial success as has been achieved for other inherited …

Hyaluronic-acid-modified lipid-polymer hybrid nanoparticles as an efficient ocular delivery platform for moxifloxacin hydrochloride

D Liu, Y Lian, Q Fang, L Liu, J Zhang, J Li - International journal of …, 2018 - Elsevier
To improve the ocular bioavailability of the strongly hydrophilic moxifloxacin hydrochloride,
hyaluronic-acid-modified lipid-polymer hybrid nanoparticles (HA-LCS-NPs) were designed …

Effective gene therapy of Stargardt disease with PEG-ECO/pGRK1-ABCA4-S/MAR nanoparticles

D Sun, W Sun, SQ Gao, J Lehrer, A Naderi… - … Therapy-Nucleic Acids, 2022 - cell.com
Stargardt disease (STGD) is the most common form of inherited retinal genetic disorders and
is often caused by mutations in ABCA4. Gene therapy has the promise to effectively treat …

Nanoparticulate drug delivery to the retina

Q Li, J Weng, SN Wong, WY Thomas Lee… - Molecular …, 2020 - ACS Publications
Retinal diseases, such as age-related macular degeneration and diabetic retinopathy, are
the leading causes of blindness worldwide. The mainstay of treatment for these blinding …

Ocular drug delivery-new strategies for targeting anterior and posterior segments of the eye

JF Fangueiro, F Veiga, AM Silva… - Current pharmaceutical …, 2016 - ingentaconnect.com
The ocular delivery of drugs encounters several limitations because of the dynamic and
static barriers of the human's eye anatomy and physiology. The poor bioavailability of drugs …