Ancestral environmental exposures such as toxicants, abnormal nutrition or stress can
promote the epigenetic transgenerational inheritance of disease and phenotypic variation …

Cryopreservation of semen and artificial insemination have an important, positive impact on
cattle production, and product quality. Through the use of cryopreserved semen and artificial …

Maternal and paternal factors influence offspring development and program its genome for
successful postnatal life. Based on the stressors during gestation, the pregnant female …

Spermiogenesis is a complex cellular differentiation process that the germ cells undergo a
distinct morphological change, and the protamines replace the core histones to facilitate …

Bioinformatic analysis can not only accelerate drug target identification and drug candidate
screening and refinement, but also facilitate characterization of side effects and predict drug …

Background Infertility is a common reproductive disorder, with male factor infertility
accounting for approximately half of all cases. Taking a paternal perceptive, recent research …

Bisphenol A (BPA) is an endocrine-disrupting chemical widely distributed in the
environment. Its exposure has been linked to male infertility in animals and humans due to …

Many environmental toxicants have been shown to be associated with the transgenerational
inheritance of increased disease susceptibility. This review describes the generational …

BACKGROUND Over the past few years, advances in molecular technologies have allowed
unprecedented mapping of epigenetic modifications in gametes and during early embryonic …

Mitochondrial fusion and fission (mitochondrial dynamics) are homeostatic processes that
safeguard normal cellular function. This relationship is especially strong in tissues with …