[HTML][HTML] Dissemination and prevalence of plasmid-mediated high-level tigecycline resistance gene tet (X4)

S Zhang, J Wen, Y Wang, M Wang, R Jia… - Frontiers in …, 2022 - frontiersin.org
With the large-scale use of antibiotics, antibiotic resistant bacteria (ARB) continue to rise,
and antibiotic resistance genes (ARGs) are regarded as emerging environmental pollutants …

Molecular mechanisms of tigecycline-resistance among Enterobacterales

L Korczak, P Majewski, D Iwaniuk, P Sacha… - Frontiers in Cellular …, 2024 - frontiersin.org
The global emergence of antimicrobial resistance to multiple antibiotics has recently
become a significant concern. Gram-negative bacteria, known for their ability to acquire …

Structure and mechanism for streptococcal fatty acid kinase (Fak) system dedicated to host fatty acid scavenging

Y Shi, N Zang, N Lou, Y Xu, J Sun, M Huang… - Science …, 2022 - science.org
Staphylococcus and Streptococcus, two groups of major human pathogens, are equipped
with a fatty acid kinase (Fak) machinery to scavenge host fatty acids. The Fak complex is …

[HTML][HTML] Antibiotic resistance of Riemerella anatipestifer and comparative analysis of antibiotic-resistance gene detection methods

Z Xihui, L Yanlan, W Zhiwei, P Zheyu, S Zhenshu… - Poultry Science, 2023 - Elsevier
Riemerella anatipestifer is an important pathogen in waterfowl, and is generally multidrug
resistant. This study assessed the current status of Riemerella anatipestifer antibiotic …

Source Tracking and Global Distribution of the Tigecycline Non-Susceptible tet(X)

R Zhang, J Sun, R Sun, M Wang, C Cui… - Microbiology …, 2021 - Am Soc Microbiol
The emergence of tet (X) genes has compromised the clinical use of the last-line antibiotic
tigecycline. We identified 322 (1.21%) tet (X) positive samples from 12,829 human …

Emergence and mobilization of a novel lincosamide resistance gene lnu (I): from environmental reservoirs to pathogenic bacteria

Z Yang, T Lan, H Luo, P Li, M Wang, R Jia… - Science of The Total …, 2024 - Elsevier
Antimicrobial resistance remains an utmost concern in human and veterinary medicine,
impacting humans, animals, and the environment while significantly influencing the …

[HTML][HTML] Sequence-structure-function characterization of the emerging tetracycline destructase family of antibiotic resistance enzymes

KS Blake, H Kumar, A Loganathan, EE Williford… - Communications …, 2024 - nature.com
Tetracycline destructases (TDases) are flavin monooxygenases which can confer resistance
to all generations of tetracycline antibiotics. The recent increase in the number and diversity …

[HTML][HTML] Metagenomic insights into the antibiotic resistomes of typical Chinese dairy farm environments

J Kang, Y Liu, X Chen, F Xu, H Wang… - Frontiers in …, 2022 - frontiersin.org
Antibiotic resistance genes (ARGs) in the environment pose a threat to human and animal
health. Dairy cows are important livestock in China; however, a comprehensive …

Phenotypic and genomic analysis reveals Riemerella anatipestifer as the potential reservoir of tet(X) variants

R Li, Y Jiang, K Peng, Y Wang, M Wang… - Journal of …, 2022 - academic.oup.com
Background Tigecycline is regarded as one of the last-resort antimicrobials clinically.
Emergence of plasmid-mediated tet (X) undermines such an important drug. However, the …

[HTML][HTML] Emergence of plasmid-mediated tigecycline, β-lactam and florfenicol resistance genes tet (X), blaOXA-347 and floR in Riemerella anatipestifer isolated in …

D Zhu, X Wei, H Zhu, Z Yang, M Wang, R Jia, S Chen… - Poultry Science, 2022 - Elsevier
Bacterial antimicrobial resistance (AMR) continues to develop, with the horizontal transfer of
antibiotic resistance genes (ARGs) through plasmids playing a major role. Recently, the …