The presence, magnitude, and significance of sex differences in the human brain are hotly
debated topics in the scientific community and popular media. This debate is largely fueled …

Disorders of the nervous system are challenging to study and treat due to the relative
inaccessibility of functional human brain tissue for research. Stem cell-derived 3D human …

Elucidating the cellular organization of the cerebral cortex is critical for understanding brain
structure and function. Using large-scale single-nucleus RNA sequencing and spatial …

Generation of genetically uniform non-human primates may help to establish animal models
for primate biology and biomedical research. In this study, we have successfully cloned …

INTRODUCTION Improved understanding of how the developing human nervous system
differs from that of closely related nonhuman primates is fundamental for teasing out human …

Mutation or disruption of the SH3 and ankyrin repeat domains 3 (SHANK3) gene represents
a highly penetrant, monogenic risk factor for autism spectrum disorder, and is a cause of …

Targeted integration of transgenes can be achieved by strategies based on homologous
recombination (HR), microhomology-mediated end joining (MMEJ) or non-homologous end …

Anxiety disorders impose a staggering burden on public health, underscoring the need to
develop a deeper understanding of the distributed neural circuits underlying extreme fear …

Delivering genes to and across the brain vasculature efficiently and specifically across
species remains a critical challenge for addressing neurological diseases. We have evolved …

The CRISPR/Cas9 system is an efficient gene-editing method, but the majority of gene-
edited animals showed mosaicism, with editing occurring only in a portion of cells. Here we …