Challenges and lessons learned from COVID-19 trials: should we be doing clinical trials differently?
The COVID-19 crisis led to a flurry of clinical trials activity. The COVID-evidence database
shows 2814 COVID-19 randomized trials registered as of February 16, 2021. Most were …
shows 2814 COVID-19 randomized trials registered as of February 16, 2021. Most were …
Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study
Objective To estimate the effect of extracorporeal membrane oxygenation (ECMO)
compared with conventional mechanical ventilation on outcomes of patients with covid-19 …
compared with conventional mechanical ventilation on outcomes of patients with covid-19 …
Challenges and solutions in clinical research during the COVID‐19 pandemic: A narrative review
Abstract Background and Aims The COVID‐19 pandemic has presented significant
challenges to clinical research, necessitating the adoption of innovative and remote …
challenges to clinical research, necessitating the adoption of innovative and remote …
Results reporting for clinical trials led by medical universities and university hospitals in the Nordic countries was often missing or delayed
G Nilsonne, S Wieschowski, NJ DeVito… - MedRxiv, 2024 - medrxiv.org
Objective: To systematically evaluate timely reporting of clinical trial results at medical
universities and university hospitals in the Nordic countries. Study Design and Setting: In this …
universities and university hospitals in the Nordic countries. Study Design and Setting: In this …
Dissemination of Registered COVID-19 Clinical Trials (DIRECCT): a cross-sectional study
M Salholz-Hillel, M Pugh-Jones, N Hildebrand… - BMC medicine, 2023 - Springer
Background The results of clinical trials should be completely and rapidly reported during
public health emergencies such as COVID-19. This study aimed to examine when, and …
public health emergencies such as COVID-19. This study aimed to examine when, and …
How informative were early SARS-CoV-2 treatment and prevention trials? A longitudinal cohort analysis of trials registered on ClinicalTrials. gov
N Hutchinson, K Klas, BG Carlisle, J Kimmelman… - Plos one, 2022 - journals.plos.org
Background Early in the SARS-CoV-2 pandemic, commentators warned that some COVID
trials were inadequately conceived, designed and reported. Here, we retrospectively assess …
trials were inadequately conceived, designed and reported. Here, we retrospectively assess …
Results availability and timeliness of registered COVID-19 clinical trials: interim cross-sectional results from the DIRECCT study
M Salholz-Hillel, P Grabitz, M Pugh-Jones, D Strech… - BMJ open, 2021 - bmjopen.bmj.com
Objective To examine how and when the results of COVID-19 clinical trials are
disseminated. Design Cross-sectional study. Setting The COVID-19 clinical trial landscape …
disseminated. Design Cross-sectional study. Setting The COVID-19 clinical trial landscape …
Factors that impact on recruitment to vaccine trials in the context of a pandemic or epidemic: a qualitative evidence synthesis
Background The World Health Organization declared the COVID‐19 pandemic on 11 March
2020. Vaccine development and deployment were swiftly prioritised as a method to manage …
2020. Vaccine development and deployment were swiftly prioritised as a method to manage …
Target and actual sample sizes for studies from two trial registries from 1999 to 2020: an observational study
AG Barnett, P Glasziou - BMJ Open, 2021 - bmjopen.bmj.com
Objectives To investigate differences between target and actual sample sizes, and what
study characteristics were associated with sample sizes. Design Observational study …
study characteristics were associated with sample sizes. Design Observational study …
Hydroxychloroquine to prevent SARS-Cov-2 infection among Healthcare workers: early termination of a phase 3, randomised, open-label, controlled clinical trial
A Llanos-Cuentas, A Schwalb, JL Quintana, B Delfin… - BMC research …, 2023 - Springer
Objective To assess the effectiveness and safety of hydroxychloroquine (HCQ) prophylaxis
for the prevention of SARS-CoV-2 infection in healthcare workers (HCW) on duty during the …
for the prevention of SARS-CoV-2 infection in healthcare workers (HCW) on duty during the …