Heparan sulfate (HS) are complex unbranched carbohydrate chains that are heavily
modified by sulfate and exist either conjugated to proteins or as free, unconjugated chains …

Glypicans are a family of heparan sulfate proteoglycans that are attached to the cell
membrane via a glycosylphosphatidylinositol anchor. Glypicans interact with multiple …

Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-related death
in the world, and curative systemic therapies are lacking. Chimeric antigen receptor (CAR) …

Purpose: The carcinoembryonic antigen glypican-3 (GPC3) is an ideal target of anticancer
immunotherapy against hepatocellular carcinoma (HCC). In this nonrandomized, open …

Background Genome assemblers have grown very large and complex in response to the
need for algorithms to handle the challenges of large whole-genome sequencing projects …

Proteoglycans are a group of molecules that contain at least one glycosaminoglycan chain,
such as a heparan, dermatan, chondroitin, or keratan sulfate, covalently attached to the …

Abstract Glypican-3 (GPC3) is a cell-surface glycoprotein that is frequently overexpressed in
hepatocellular carcinoma (HCC). GPC3 undergoes extensive posttranslational modification …

Abstract Glypican 3 (GPC3), a membrane-bound heparin sulfate proteoglycan, may play a
role in promoting embryonic cell growth and differentiation. GPC3 is mutated in Simpson …

Distinguishing a well-differentiated hepatocellular carcinoma (HCC) from normal and
cirrhotic liver tissue or benign liver nodules, such as hepatic adenoma (HA) and focal …

Abstract Glypican-3 (GPC3) is a heparan sulfate proteoglycan that plays an important role in
cell growth and differentiation. GPC3 function is tissue dependent. In some tissues, GPC3 …