Adult hippocampal neurogenesis and cognitive flexibility—linking memory and mood
Adult hippocampal neurogenesis has been implicated in cognitive processes, such as
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …
Adult neurogenesis in the hippocampus: from stem cells to behavior
The dentate gyrus of the mammalian hippocampus continuously generates new neurons
during adulthood. These adult-born neurons become functionally active and are thought to …
during adulthood. These adult-born neurons become functionally active and are thought to …
Adult-born dentate granule cells promote hippocampal population sparsity
The dentate gyrus (DG) gates neocortical information flow to the hippocampus. Intriguingly,
the DG also produces adult-born dentate granule cells (abDGCs) throughout the lifespan …
the DG also produces adult-born dentate granule cells (abDGCs) throughout the lifespan …
Neurogenesis in aging and age-related neurodegenerative diseases
Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …
adult brain, declines in an age-dependent manner and is one potential target for extending …
Time cells in the hippocampus: a new dimension for mapping memories
H Eichenbaum - Nature Reviews Neuroscience, 2014 - nature.com
Recent studies have revealed the existence of hippocampal neurons that fire at successive
moments in temporally structured experiences. Several studies have shown that such …
moments in temporally structured experiences. Several studies have shown that such …
The brain in motion: How ensemble fluidity drives memory-updating and flexibility
W Mau, ME Hasselmo, DJ Cai - Elife, 2020 - elifesciences.org
While memories are often thought of as flashbacks to a previous experience, they do not
simply conserve veridical representations of the past but must continually integrate new …
simply conserve veridical representations of the past but must continually integrate new …
Transcending time in the brain: How event memories are constructed from experience
Our daily lives unfold continuously, yet when we reflect on the past, we remember those
experiences as distinct and cohesive events. To understand this phenomenon, early …
experiences as distinct and cohesive events. To understand this phenomenon, early …
Assessments of dentate gyrus function: discoveries and debates
There has been considerable speculation regarding the function of the dentate gyrus (DG)—
a subregion of the mammalian hippocampus—in learning and memory. In this Perspective …
a subregion of the mammalian hippocampus—in learning and memory. In this Perspective …
Hippocampal neurogenesis: learning to remember
O Lazarov, C Hollands - Progress in neurobiology, 2016 - Elsevier
Alzheimer's disease, the most prevalent form of dementia in the elderly, is characterized by
progressive memory loss and cognitive dysfunction. It has become increasingly clear that …
progressive memory loss and cognitive dysfunction. It has become increasingly clear that …
The neural bases for timing of durations
Durations are defined by a beginning and an end, and a major distinction is drawn between
durations that start in the present and end in the future ('prospective timing') and durations …
durations that start in the present and end in the future ('prospective timing') and durations …