Adult hippocampal neurogenesis and cognitive flexibility—linking memory and mood

C Anacker, R Hen - Nature Reviews Neuroscience, 2017 - nature.com
Adult hippocampal neurogenesis has been implicated in cognitive processes, such as
pattern separation, and in the behavioural effects of stress and antidepressants. Young adult …

Adult neurogenesis in the hippocampus: from stem cells to behavior

JT Gonçalves, ST Schafer, FH Gage - Cell, 2016 - cell.com
The dentate gyrus of the mammalian hippocampus continuously generates new neurons
during adulthood. These adult-born neurons become functionally active and are thought to …

Adult-born dentate granule cells promote hippocampal population sparsity

SB McHugh, V Lopes-dos-Santos, GP Gava… - Nature …, 2022 - nature.com
The dentate gyrus (DG) gates neocortical information flow to the hippocampus. Intriguingly,
the DG also produces adult-born dentate granule cells (abDGCs) throughout the lifespan …

Neurogenesis in aging and age-related neurodegenerative diseases

L Culig, X Chu, VA Bohr - Ageing research reviews, 2022 - Elsevier
Adult neurogenesis, the process by which neurons are generated in certain areas of the
adult brain, declines in an age-dependent manner and is one potential target for extending …

Time cells in the hippocampus: a new dimension for mapping memories

H Eichenbaum - Nature Reviews Neuroscience, 2014 - nature.com
Recent studies have revealed the existence of hippocampal neurons that fire at successive
moments in temporally structured experiences. Several studies have shown that such …

The brain in motion: How ensemble fluidity drives memory-updating and flexibility

W Mau, ME Hasselmo, DJ Cai - Elife, 2020 - elifesciences.org
While memories are often thought of as flashbacks to a previous experience, they do not
simply conserve veridical representations of the past but must continually integrate new …

Transcending time in the brain: How event memories are constructed from experience

D Clewett, S DuBrow, L Davachi - Hippocampus, 2019 - Wiley Online Library
Our daily lives unfold continuously, yet when we reflect on the past, we remember those
experiences as distinct and cohesive events. To understand this phenomenon, early …

Assessments of dentate gyrus function: discoveries and debates

M Borzello, S Ramirez, A Treves, I Lee… - Nature Reviews …, 2023 - nature.com
There has been considerable speculation regarding the function of the dentate gyrus (DG)—
a subregion of the mammalian hippocampus—in learning and memory. In this Perspective …

Hippocampal neurogenesis: learning to remember

O Lazarov, C Hollands - Progress in neurobiology, 2016 - Elsevier
Alzheimer's disease, the most prevalent form of dementia in the elderly, is characterized by
progressive memory loss and cognitive dysfunction. It has become increasingly clear that …

The neural bases for timing of durations

A Tsao, SA Yousefzadeh, WH Meck… - Nature reviews …, 2022 - nature.com
Durations are defined by a beginning and an end, and a major distinction is drawn between
durations that start in the present and end in the future ('prospective timing') and durations …