Most complex trait-associated variants are located in non-coding regulatory regions of the
genome, where they have been shown to disrupt transcription factor (TF)-DNA binding …

The vast majority of the genetic variants (mainly SNPs) associated with various human traits
and diseases map to a noncoding part of the genome and are enriched in its regulatory …

During the past decade, user privacy has become an important issue in networked
computing environments. For instance, mobile applications and devices are increasingly …

Single nucleotide polymorphisms (SNPs) in the human genome are DNA sequence
variations that can alter an individual's response to environmental exposure. SNPs in gene …

Motivation: Determining the functional impact of non-coding disease-associated single
nucleotide polymorphisms (SNPs) identified by genome-wide association studies (GWAS) is …

Motivation: Our understanding of gene regulation is currently limited by our ability to
collectively synthesize and catalogue transcriptional regulatory elements stored in scientific …

Background The invention of high throughput sequencing technologies has led to the
discoveries of hundreds of thousands of genetic variants associated with thousands of …

Motivation: Protein–nucleic acid interactions are fundamental to the regulation of gene
expression. In order to elucidate the molecular mechanism of protein–nucleic acid …

Since the human genome was sequenced in draft, single nucleotide polymorphism (SNP)
analysis has become one of the keynote fields of bioinformatics. We have developed an …

While year after year, conditions, quality, and duration of human lives have been improving
due to the progress in science, technology, education, and medicine, only eight diseases …