Monoamine oxidase inhibitors were among the first antidepressants to be discovered and
have long been used as such. It now seems that many of these agents might have …

Drug addiction manifests as a compulsive drive to take a drug despite serious adverse
consequences. This aberrant behaviour has traditionally been viewed as bad'choices' that …

Tobacco seems to have additional effects beyond nicotine. In the trivial sense, tobacco
smoke is made up of thousands of chemicals. The more interesting question is whether any …

Population aging is one of the most significant social changes of the twenty-first century. This
increase in longevity is associated with a higher prevalence of chronic diseases, further …

Modern imaging techniques enable researchers to observe drug actions and consequences
as they occur and persist in the brains of abusing and addicted individuals. This article …

Monoamine oxidase (MAO) is a mitochondrial outer-membrane flavoenzyme involved in
brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines …

Several reversible inhibitors selective for human monoamine oxidase B (MAO B) that do not
inhibit MAO A have been described in the literature. The following compounds: 8-(3 …

While most cigarette smokers endorse a desire to quit smoking, only about 14% to 49% will
achieve abstinence after 6 months or more of treatment. A greater understanding of the …

It would not be practical to attempt to deal with all the advances that have informed our
understanding of the behavior and functions of this enzyme over the past 90 years. This …

Highlights•Accelerated aging happens when biological age outpaces chronological age.•In
addiction the early-onset of comorbid diseases remains mostly undetected.•Oxidation …