The microtubule network of cardiac muscle cells has unique architectural and biophysical
features to accommodate the demands of the working heart. Advances in live-cell imaging …

As our understanding of the cell interior has grown, we have come to appreciate that most
cellular operations are localized, that is, they occur at discrete and identifiable locations or …

The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

Calmodulin (CaM) plays critical roles in cardiomyocytes, regulating Na+ (NaV) and L-type
Ca2+ channels (LTCCs). LTCC dysregulation by mutant CaMs has been implicated in action …

The sarcoplasmic reticulum of skeletal muscle cells is a highly ordered structure consisting
of an intricate network of tubules and cisternae specialized for regulating Ca2+ homeostasis …

Cardiac multiscale bioimaging is an emerging field that aims to provide a comprehensive
understanding of the heart and its functions at various levels, from the molecular to the entire …

This white paper is the outcome of the seventh UC Davis Cardiovascular Research
Symposium on Systems Approach to Understanding Cardiovascular Disease and …

During chronic stress, persistent activation of cAMP-dependent protein kinase (PKA) occurs,
which can contribute to protective or maladaptive changes in the heart. We sought to …

Background Propagation of action potentials through the heart coordinates the heartbeat.
Thus, intercalated discs, specialized cell–cell contact sites that provide electrical and …

Cardiac muscle contraction is regulated via Ca2+ exchange with the hetero-trimeric troponin
complex located on the thin filament. Binding of Ca2+ to cardiac troponin C, a Ca2+ sensing …