CRISPR-Cas clinical trials have begun, offering a first glimpse at how DNA and RNA
targeting could enable therapies for many genetic and epigenetic human diseases. The …

Deletion of SCN9A encoding the voltage-gated sodium channel Na V 1.7 in humans leads
to profound pain insensitivity and anosmia. Conditional deletion of Na V 1.7 in sensory …

Pain is an evolved biological mechanism designed to let our brain know when a certain part
of our body is damaged. Nociceptors are specialized neurons equipped with ion channels …

Objective (s): Tissue injury in peripheral sites can result in long-term potentiation in
nociceptive neurons and surrounding glial cells, potentially resulting in the development of …

As reviewed previously (chapter “Principles and Targets Underlying Spinal Analgesia”),
systematic study of the biology of the neuraxial processing generated by tissue and nerve …

The development of drugs for spinal delivery has advanced along with both our increasing
understanding of the biology of spinal function and the development of novel therapies …

Deletion of SCN9A encoding the voltage-gated sodium channel NaV1. 7 in humans leads to
profound pain insensitivity and anosmia. Conditional deletion of NaV1. 7 in sensory neurons …

The chapter provides an overview of the risk of misuse assessment and applies findings
from the assessment to determine how likely state and non-state actors are to use genome …