HFIP in organic synthesis

HF Motiwala, AM Armaly, JG Cacioppo… - Chemical …, 2022 - ACS Publications
1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

Photochemical and electrochemical applications of proton-coupled electron transfer in organic synthesis

PRD Murray, JH Cox, ND Chiappini, CB Roos… - Chemical …, 2021 - ACS Publications
We present here a review of the photochemical and electrochemical applications of multi-
site proton-coupled electron transfer (MS-PCET) in organic synthesis. MS-PCETs are redox …

Cross-dehydrogenative coupling: a sustainable reaction for C–C bond formations

T Tian, Z Li, CJ Li - Green Chemistry, 2021 - pubs.rsc.org
We are entering an era that emphasizes greenness and sustainability. Based on such a
philosophy, it is critical to uncover novel and original sustainable reaction modes for future …

A decade of electrochemical dehydrogenative C, C-coupling of aryls

JL Röckl, D Pollok, R Franke… - Accounts of Chemical …, 2019 - ACS Publications
Conspectus The importance of sustainable and green synthetic protocols for the synthesis of
fine chemicals has rapidly increased during the last decades in an effort to reduce the use of …

Electrochemical arylation reaction

SR Waldvogel, S Lips, M Selt, B Riehl… - Chemical …, 2018 - ACS Publications
Arylated products are found in various fields of chemistry and represent essential entities for
many applications. Therefore, the formation of this structural feature represents a central …

Use of boron‐doped diamond electrodes in electro‐organic synthesis

S Lips, SR Waldvogel - ChemElectroChem, 2019 - Wiley Online Library
Boron‐doped diamond is a powerful and innovative material with outstanding properties,
experiencing a strongly emerging interest in the chemical society as electrode material. BDD …

use of 1, 1, 1, 3, 3, 3–hexafluoro–2–propanol (HFIP) Co-solvent mixtures in organic electrosynthesis

JM Ramos-Villaseñor… - Journal of the …, 2020 - iopscience.iop.org
Because of the necessity of carry out electrolysis reactions with considerable quantity of
organic molecules, the balance between solubility of starting material, solution conductivity …

Solvent control in electro-organic synthesis

L Schulz, SR Waldvogel - Synlett, 2019 - thieme-connect.com
Exploiting the solvent control within electro-organic conversions is a far underestimated
parameter in prep-scale electrolysis. The beneficial application in several transformations is …

Dehydrogenative Anodic C− C Coupling of Phenols Bearing Electron‐Withdrawing Groups

JL Röckl, D Schollmeyer, R Franke… - Angewandte Chemie …, 2020 - Wiley Online Library
We herein present a metal‐free, electrosynthetic method that enables the direct
dehydrogenative coupling reactions of phenols carrying electron‐withdrawing groups for the …

Regioselective metal‐and reagent‐free arylation of benzothiophenes by dehydrogenative electrosynthesis

S Lips, D Schollmeyer, R Franke… - Angewandte Chemie …, 2018 - Wiley Online Library
A novel strategy for the synthesis of biaryls consisting of a benzothiophene and a phenol
moiety is reported. These heterobiaryls are of utmost interest for pharmaceutical, biological …