Advances in psoriasis physiopathology and treatments: up to date of mechanistic insights and perspectives of novel therapies based on innovative skin drug delivery …

M Sala, A Elaissari, H Fessi - Journal of Controlled Release, 2016 - Elsevier
Psoriasis is a chronic inflammatory disease affecting mainly the skin but which can be
complicated by psoriatic arthritis (PsA). This autoimmune skin disorder concerns 2–5% of …

Tackling the various classes of nano-therapeutics employed in topical therapy of psoriasis

SA Fereig, GM El-Zaafarany, MG Arafa… - Drug …, 2020 - Taylor & Francis
Psoriasis is a dermatological chronic skin condition with underlying autoimmune etiology. It
deeply affects patients' quality of life. Therefore, it was an interesting target for researchers …

Application of quality by design in optimization of nanoformulations: Principle, perspectives and practices

D Birla, N Khandale, B Bashir, M ShahbazAlam… - Drug Delivery and …, 2024 - Springer
Nanoparticulate drug delivery systems (NDDS) based nanoformulations have emerged as
promising drug delivery systems. Various NDDS-based formulations have been reported …

Formulation, in-vitro and in-vivo pharmacokinetic evaluation of simvastatin nanostructured lipid carrier loaded transdermal drug delivery system

S Brito Raj, KB Chandrasekhar, KB Reddy - Future Journal of …, 2019 - Springer
Background A simvastatin nanostructured lipid carrier loaded transdermal patch was
developed to enhance the bioavailability and therapeutic effect. Methods Simvastatin NLC …

Comparative evaluation of dithranol-loaded nanosponges fabricated by solvent evaporation technique and melt method

V Kadian, P Dalal, S Kumar, A Kapoor… - Future Journal of …, 2023 - Springer
Background Dithranol, a standard drug for psoriasis, has lured keen attention by virtue of its
antioxidant, anti-proliferative and anti-inflammatory activities. However, its poor stability and …

Hydrogel containing PEG-coated fluconazole nanoparticles with enhanced solubility and antifungal activity

AAH Abdellatif, DFA El-Telbany, G Zayed… - Journal of …, 2019 - Springer
Purpose The aim of this study was to prepare fluconazole (FLC) nanoparticles coated with
polyethylene glycol (PEG) in the form of FLC-PEG-NPs and optimize the size and …

Dithranol-loaded lipid-core nanocapsules improve the photostability and reduce the in vitro irritation potential of this drug

AL Savian, D Rodrigues, J Weber, RF Ribeiro… - Materials Science and …, 2015 - Elsevier
Dithranol is a very effective drug for the topical treatment of psoriasis. However, it has some
adverse effects such as irritation and stain in the skin that make its application and patient …

Hyaluronic acid-coated solid lipid nanoparticles enhance antirheumatic activity and reduce toxicity of methotrexate

Y Mirchandani, VB Patravale, S Brijesh - Nanomedicine, 2022 - Taylor & Francis
Aim: Methotrexate (MTX) is used to treat rheumatoid arthritis (RA) but is associated with
severe toxicity. To minimize these side effects of MTX, the study was undertaken to explore …

Intranasal repaglinide-solid lipid nanoparticles integrated in situ gel outperform conventional oral route in hypoglycemic activity

SM Elkarray, RM Farid, MM Abd-Alhaseeb… - Journal of Drug Delivery …, 2022 - Elsevier
Repaglinide (REP) loaded solid-lipid nanoparticles (SLNs) for intranasal administration is
the subject of the current work aiming enhancement of diabetes pharmacotherapy. SLNs …

[PDF][PDF] Novel topical drug carriers as a tool for treatment of psoriasis: progress and advances

PK Suresh, P Singh, S Saraf - Afr J Pharm Pharmacol, 2013 - academicjournals.org
Psoriasis is a chronic inflammatory skin disease portrayed by erythematous,
papulosquamous lesions. It is characterized by excessive growth and aberrant …