Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Histone lysine crotonylation (Kcr), a novel posttranslational modification, is widespread as
acetylation (Kac); however, its roles are largely unknown. In this study, we report that histone …

Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …

In eukaryotic cells, DNA is tightly packed with the help of histone proteins into chromatin.
Chromatin architecture can be modified by various post‐translational modifications of …

Lysine crotonylation has been discovered in histone and non-histone proteins and found to
be involved in diverse diseases and biological processes, such as neuropsychiatric disease …

Metabolites affect cell growth in two different ways. First, they serve as building blocks for
biomass accumulation. Second, metabolites regulate the activity of growth-relevant …

The emergence of a nucleosome-based chromatin structure accompanied the evolutionary
transition from prokaryotes to eukaryotes. In this scenario, histones became the heart of the …

Histone crotonylation is a newly identified epigenetic modification that has a pronounced
ability to regulate gene expression. It belongs to an expanding group of short chain lysine …

The metabolism of glucose and lipids is essential for energy production in the body, and
dysregulation of the metabolic pathways of these molecules is implicated in various acute …