Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are
a considerable global challenge. Despite the huge number of people infected, NDs do not …

Neglected tropical diseases (NTDs) affect millions of people in different geographic regions,
especially the poorest and most vulnerable. Currently NTDs are prevalent in 149 countries …

The cysteine proteases, cruzain and Tbr CATL (rhodesain), are therapeutic targets for
Chagas disease and Human African Trypanosomiasis, respectively. Among the known …

Chagas disease (CD), also known as American trypanosomiasis, is caused by the
flagellated protozoan Trypanosoma cruzi, and affects an estimated 8 to 10 million people …

Chagas disease is a neglected tropical disease caused by the protozoan Trypanosoma
cruzi. Benznidazole and nifurtimox are the two approved drugs for their treatment, but both …

Hybrid bioisoster derivatives from N-acylhydrazones and furoxan groups were designed
with the objective of obtaining at least a dual mechanism of action: cruzain inhibition and …

A rational approach was used to synthesize a new set of 15 1 H-1, 2, 4-triazol-3-yl
benzenesulfonamide derivatives with the aim of developing new antimalarial lead …

Background Leishmaniasis includes a wide complex of diseases that affect humans and
other mammals, and can range from a mild cutaneous form to a severe visceral type. The …

Almost 110 years after the first studies by Dr. Carlos Chagas describing an infectious
disease that was named for him, Chagas disease remains a neglected illness and a death …

Chagas disease is a leading public health problem. More than 8 million people are affected
by the disease, which is endemic in 21 countries in Latin America, generating an average …