Molecular components of the Mammalian circadian clock

ED Buhr, JS Takahashi - Circadian clocks, 2013 - Springer
Mammals synchronize their circadian activity primarily to the cycles of light and darkness in
the environment. This is achieved by ocular photoreception relaying signals to the …

Physiology of circadian entrainment

DA Golombek, RE Rosenstein - Physiological reviews, 2010 - journals.physiology.org
Mammalian circadian rhythms are controlled by endogenous biological oscillators, including
a master clock located in the hypothalamic suprachiasmatic nuclei (SCN). Since the period …

Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

SE Jones, JM Lane, AR Wood, VT van Hees… - Nature …, 2019 - nature.com
Being a morning person is a behavioural indicator of a person's underlying circadian rhythm.
Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase …

Type 2 innate lymphoid cells control eosinophil homeostasis

JC Nussbaum, SJ Van Dyken, J Von Moltke, LE Cheng… - Nature, 2013 - nature.com
Eosinophils are specialized myeloid cells associated with allergy and helminth infections.
Blood eosinophils demonstrate circadian cycling, as described over 80 years ago, and are …

[HTML][HTML] Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system

M Iwasaki, Y Akiba, JD Kaunitz - F1000Research, 2019 - ncbi.nlm.nih.gov
Vasoactive intestinal peptide (VIP), a gut peptide hormone originally reported as a
vasodilator in 1970, has multiple physiological and pathological effects on development …

Suprachiasmatic nucleus: cell autonomy and network properties

DK Welsh, JS Takahashi, SA Kay - Annual review of physiology, 2010 - annualreviews.org
The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals.
Individual SCN neurons in dispersed culture can generate independent circadian …

The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity

C Seillet, K Luong, J Tellier, N Jacquelot, RD Shen… - Nature …, 2020 - nature.com
Group 3 innate lymphoid cell (ILC3)-mediated production of the cytokine interleukin-22 (IL-
22) is critical for the maintenance of immune homeostasis in the gastrointestinal tract. Here …

Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery

D Vaudry, A Falluel-Morel, S Bourgault, M Basille… - Pharmacological …, 2009 - ASPET
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38-amino acid C-terminally
α-amidated peptide that was first isolated 20 years ago from an ovine hypothalamic extract …

Genetics of circadian rhythms in Mammalian model organisms

PL Lowrey, JS Takahashi - Advances in genetics, 2011 - Elsevier
The mammalian circadian system is a complex hierarchical temporal network which is
organized around an ensemble of uniquely coupled cells comprising the principal circadian …

Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase‐activating polypeptide: IUPHAR review 1

AJ Harmar, J Fahrenkrug, I Gozes… - British journal of …, 2012 - Wiley Online Library
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase‐activating polypeptide
(PACAP) are members of a superfamily of structurally related peptide hormones that …