With the development of whole genome and transcriptome sequencing technologies, long
noncoding RNAs (lncRNAs) have received increased attention. Multiple studies indicate that …

Despite their known importance in clinical medicine, differences based on sex and gender
are among the least studied factors affecting cancer susceptibility, progression, survival, and …

Abstract Purpose: BRCA1/2-mutated and some sporadic triple-negative breast cancers
(TNBC) have DNA repair defects and are sensitive to DNA-damaging therapeutics …

Intratumor heterogeneity is a major clinical problem because tumor cell subtypes display
variable sensitivity to therapeutics and may play different roles in progression. We previously …

The TEAD transcription factor family is best known for transcriptional output of the Hippo
signaling pathway and has been implicated in processes such as development, cell growth …

Triple-negative breast cancer, so called because it lacks expression of the estrogen
receptor, progesterone receptor, and HER2, is often, but not always, a basal-like breast …

The discovery of numerous noncoding RNA (ncRNA) transcripts in species from yeast to
mammals has dramatically altered our understanding of cell biology, especially the biology …

Lacking a self-contained metabolism network, viruses have evolved multiple mechanisms
for rewiring the metabolic system of their host to hijack the host's metabolic resources for …

Most tumors exhibit increased glucose metabolism to lactate, however, the extent to which
glucose-derived metabolic fluxes are used for alternative processes is poorly understood …

DNA repair competency is one determinant of sensitivity to certain chemotherapy drugs,
such as cisplatin. Cancer cells with intact DNA repair can avoid the accumulation of genome …