Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process optimization approaches

A Ziaee, AB Albadarin, L Padrela, T Femmer… - European Journal of …, 2019 - Elsevier
Spray drying is increasingly becoming recognized as an efficient drying and formulation
technique for pharmaceutical and biopharmaceutical processing. It offers significant …

Pharmaceutical Particle Engineering via Spray Drying

R Vehring - Pharmaceutical research, 2008 - Springer
This review covers recent developments in the area of particle engineering via spray drying.
The last decade has seen a shift from empirical formulation efforts to an engineering …

Particle engineering for pulmonary drug delivery

AHL Chow, HHY Tong, P Chattopadhyay… - Pharmaceutical …, 2007 - Springer
With the rapidly growing popularity and sophistication of inhalation therapy, there is an
increasing demand for tailor-made inhalable drug particles capable of affording the most …

Challenges in delivering therapeutic peptides and proteins: A silk-based solution

J Wu, JK Sahoo, Y Li, Q Xu, DL Kaplan - Journal of Controlled Release, 2022 - Elsevier
Peptide-and protein-based therapeutics have drawn significant attention over the past few
decades for the treatment of infectious diseases, genetic disorders, oncology, and many …

Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation and process attributes

JT Pinto, E Faulhammer, J Dieplinger, M Dekner… - Drying …, 2021 - Taylor & Francis
Spray-drying is an inherently continuous and well-established industrial drying process. It
can accelerate manufacturing of biopharmaceuticals and vaccine products, resulting in both …

Pulmonary drug delivery strategies: A concise, systematic review

JS Patil, S Sarasija - Lung India, 2012 - journals.lww.com
Because of limitations associated with the conventional treatment of various chronic
diseases a growing attention has been given to the development of targeted drug delivery …

In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery

M Sakagami - Advanced drug delivery reviews, 2006 - Elsevier
Despite the interest in systemic delivery of therapeutic molecules including macromolecular
proteins and peptides via the lung, the accurate assessment of their pulmonary …

Particle engineering techniques for inhaled biopharmaceuticals

SA Shoyele, S Cawthorne - Advanced drug delivery reviews, 2006 - Elsevier
Formulation of biopharmaceuticals for pulmonary delivery is faced with the challenge of
producing particles with the optimal properties for deep lung deposition without altering the …

Pulmonary delivery of therapeutic siRNA

JKW Lam, W Liang, HK Chan - Advanced drug delivery reviews, 2012 - Elsevier
Small interfering RNA (siRNA) has a huge potential for the treatment or prevention of various
lung diseases. Once the RNA molecules have successfully entered the target cells, they …

Lactose characteristics and the generation of the aerosol

G Pilcer, N Wauthoz, K Amighi - Advanced drug delivery reviews, 2012 - Elsevier
The delivery efficiency of dry-powder products for inhalation is dependent upon the drug
formulation, the inhaler device, and the inhalation technique. Dry powder formulations are …