Drug treatments for covid-19: living systematic review and network meta-analysis

RAC Siemieniuk, JJ Bartoszko, D Zeraatkar, E Kum… - bmj, 2020 - bmj.com
Objective To compare the effects of treatments for coronavirus disease 2019 (covid-19).
Design Living systematic review and network meta-analysis. Data sources WHO covid-19 …

[HTML][HTML] Effect of tocilizumab, sarilumab, and baricitinib on mortality among patients hospitalized for COVID-19 treated with corticosteroids: a systematic review and …

AM Albuquerque, I Eckert, L Tramujas… - Clinical Microbiology …, 2023 - Elsevier
Background Randomized controlled trials (RCT) established the mortality reduction by
tocilizumab (Actemra), baricitinib (Olumiant), and sarilumab (Kevzara) in hospitalized COVID …

The role of platelet P2Y12 receptors in inflammation

WAE Parker, RF Storey - British Journal of Pharmacology, 2024 - Wiley Online Library
Inflammation is a complex pathophysiological process underlying many clinical conditions.
Platelets contribute to the thrombo‐inflammatory response. Platelet P2Y12 receptors amplify …

Efficacy of tocilizumab in the treatment of COVID‐19: An umbrella review

MM Rezaei Tolzali, M Noori, P Shokri… - Reviews in Medical …, 2022 - Wiley Online Library
Tocilizumab is an interleukin (IL)‐6 receptor inhibitor that has been proposed as a
therapeutic agent for treating coronavirus disease 2019 (COVID‐19). The aim of this …

[HTML][HTML] Association between tocilizumab, sarilumab and all-cause mortality at 28 days in hospitalised patients with COVID-19: A network meta-analysis

PJ Godolphin, DJ Fisher, LR Berry, LPG Derde… - PLoS …, 2022 - journals.plos.org
Background A recent prospective meta-analysis demonstrated that interleukin-6 antagonists
are associated with lower all-cause mortality in hospitalised patients with COVID-19 …

Viral pulmonary infection in pregnancy–Including COVID-19, SARS, influenza A, and varicella

A Maudhoo, A Khalil - Best Practice & Research Clinical Obstetrics & …, 2022 - Elsevier
The COVID-19 pandemic has been at the forefront of medicine over the last few years.
Pregnant women are often exposed to infectious agents that can be harmful not only to the …

Epigenetic memory of coronavirus infection in innate immune cells and their progenitors

JG Cheong, A Ravishankar, S Sharma, CN Parkhurst… - Cell, 2023 - cell.com
Inflammation can trigger lasting phenotypes in immune and non-immune cells. Whether and
how human infections and associated inflammation can form innate immune memory in …

[HTML][HTML] Interleukin6 prediction of mortality in critically ill COVID19 patients: A prospective observational cohort study

A Jamoussi, L Messaoud, F Jarraya, E Rachdi… - Plos one, 2023 - journals.plos.org
Objective The aim of this study is to explore the role of IL6 in predicting outcome in critically
ill COVID-19 patients. Design Prospective observational cohort study. Setting 20-bed …

Cost‐effective 3D lung tissue spheroid as a model for SARS‐CoV‐2 infection and drug screening

GASC Miranda, IA Corrêa, ÉA Amorim… - Artificial …, 2024 - Wiley Online Library
Abstract Background The SARS‐CoV‐2 pandemic has spurred an unparalleled scientific
endeavor to elucidate the virus' structure, infection mechanisms, and pathogenesis. Two …

Herbal therapy in Covid-19: A systematic review of medicinal plants effective against Covid-19

H Widoyo, ZY Mohammed… - Caspian Journal of …, 2022 - cjes.guilan.ac.ir
In 2019, a new disease called Covid-19 was detected in Wuhan located in China which
caused seriously disease or death at any age. This disease has various symptoms such as …