Fungal ribotoxins: molecular dissection of a family of natural killers
J Lacadena, E Álvarez-García… - FEMS microbiology …, 2007 - academic.oup.com
RNase T1 is the best known representative of a large family of ribonucleolytic proteins
secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among …
secreted by fungi, mostly Aspergillus and Penicillium species. Ribotoxins stand out among …
MCCE2: Improving protein pKa calculations with extensive side chain rotamer sampling
Multiconformation continuum electrostatics (MCCE) explores different conformational
degrees of freedom in Monte Carlo calculations of protein residue and ligand pKas. Explicit …
degrees of freedom in Monte Carlo calculations of protein residue and ligand pKas. Explicit …
Linking new paradigms in protein chemistry to reversible membrane-protein interactions
O Halskau, A Muga, A Martínez - Current Protein and Peptide …, 2009 - ingentaconnect.com
Amphitrophic proteins are soluble, globular proteins that may-under certain conditions-
interact reversibly with a plasma membrane. How this apparent duality in the properties of a …
interact reversibly with a plasma membrane. How this apparent duality in the properties of a …
Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat
Y Deng, J Liu, Q Zheng, D Eliezer, NR Kallenbach… - Structure, 2006 - cell.com
Coiled-coil sequences in proteins commonly share a seven-amino acid repeat with nonpolar
side chains at the first (a) and fourth (d) positions. We investigate here the role of a 3-3-1 …
side chains at the first (a) and fourth (d) positions. We investigate here the role of a 3-3-1 …
Hirsutellin A: a paradigmatic example of the insecticidal function of fungal ribotoxins
E Herrero-Galán, L García-Ortega, M Olombrada… - Insects, 2013 - mdpi.com
The fungal pathogen Hirsutella thompsonii produces an insecticidal protein named
hirsutellin A (HtA), which has been described to be toxic to several species of mites, insect …
hirsutellin A (HtA), which has been described to be toxic to several species of mites, insect …
Beauveria bassiana Ribotoxin (BbRib) Induces Silkworm Cell Apoptosis via Activating Ros Stress Response
X Ma, Q Ge, RH Taha, K Chen, Y Yuan - Processes, 2021 - mdpi.com
The BbRib gene participates in the infection process of Beauveria bassiana (B. bassiana). It
also helps pathogenic fungi to escape and defeat the insect host immune defense system by …
also helps pathogenic fungi to escape and defeat the insect host immune defense system by …
The interaction of the ribotoxin α-sarcin with complex model lipid vesicles
C García-Montoya, S García-Linares… - Archives of Biochemistry …, 2024 - Elsevier
Fungal ribotoxins are extracellular RNases that inactivate ribosomes by cleaving a single
phosphodiester bond at the universally conserved sarcin-ricin loop of the large rRNA …
phosphodiester bond at the universally conserved sarcin-ricin loop of the large rRNA …
Carboxyl pKa values, ion pairs, hydrogen bonding, and the pH-dependence of folding the hyperthermophile proteins Sac7d and Sso7d
AT Clark, K Smith, R Muhandiram… - Journal of molecular …, 2007 - Elsevier
Sac7d and Sso7d are homologous, hyperthermophile proteins with a high density of
charged surface residues and potential ion pairs. To determine the relative importance of …
charged surface residues and potential ion pairs. To determine the relative importance of …
Solution structure of hirsutellin A–new insights into the active site and interacting interfaces of ribotoxins
Hirsutellin (HtA) is intermediate in size between other ribotoxins and less specific microbial
RNases, and thus offers a unique chance to determine the minimal structural requirements …
RNases, and thus offers a unique chance to determine the minimal structural requirements …
NMR structure of the noncytotoxic α‐sarcin mutant Δ (7‐22): The importance of the native conformation of peripheral loops for activity
MF García‐Mayoral, L García‐Ortega, MP Lillo… - Protein …, 2004 - Wiley Online Library
Abstract The deletion mutant Δ (7‐22) of α‐sarcin, unlike its wild‐type protein counterpart,
lacks the specific ability to degrade rRNA in intact ribosomes and exhibits an increased …
lacks the specific ability to degrade rRNA in intact ribosomes and exhibits an increased …