Notch proteins are used repeatedly to direct developmental cell fate decisions in multiple
organs. During hematopoiesis and immune development, Notch is critical for T/B lineage …

The Notch pathway is a widely utilized, evolutionarily conserved regulatory system that plays
a central role in the fate decisions of multipotent precursor cells. Notch often acts by …

The molecular interactions provided by the thymic microenvironment that predicate T cell
development remain obscure. Here, we show that a bone marrow stromal cell line …

The Notch genes play a key role in cellular differentiation. The significance of Notch1 during
thymocyte development is well characterized, but the function of Notch2 is poorly …

The bone marrow (BM) microenvironment plays a critical role in malignant cell growth,
patient survival, and response to chemotherapy in hematologic malignancies. However …

Drug resistance remains a critical problem in the treatment of patients with multiple
myeloma. Recent studies have de-termined that Notch signaling plays a major role in bone …

Graft-versus-host disease (GVHD) represents one of the major complications of allogeneic
hematopoietic stem cell transplantation. Techniques to prevent GVHD have included ex vivo …

The systematic application of next-generation sequencing to large cohorts of oncologic
samples has opened a Pandora's box full of known and novel genetic lesions implicated in …

The Notch signaling pathway is highly evolutionarily conserved, dictating cell fate decisions
and influencing the survival and growth of progenitor cells that give rise to the cells of the …

Members of the Notch family encode transmembrane receptors that modulate differentiation,
proliferation, and apoptotic programs of many precursor cells, including hematopoietic …