Introduction A delayed second wave of brain trauma is mediated in large part by microglia
that are activated to a pro-inflammatory M1 phenotype by DAMP proteins released by dying …

Heme oxygenase (HO) family catalyzes the conversion of heme into free iron, carbon
monoxide and biliverdin. It possesses two well-characterized isoforms: HO-1 and HO-2 …

Previous studies have demonstrated that lycopene possesses anti-inflammatory properties
in the central nervous system. However, the potential role and the molecular mechanisms of …

Patients with major depression who are otherwise medically healthy have activated
inflammatory pathways in their organism. It has been described that depression is not only …

To assess the potential role of daphnetin, a clinically used anti-inflammatory agent, on the
development of the inflammatory and neurodegenerative disease, we investigated its …

Background The heme oxygenase (HO) system plays a significant role in neuroprotection
and reduction of neuroinflammation and neurodegeneration. The system, via isoforms HO-1 …

Angelicae Gigantis Radix (AGR) has been widely used as a traditional medicine in East
Asia. The effects of AGR on neuroinflammation have not previously been studied in detail. In …

KCHO-1 is a novel product comprised of 30% ethanol extracts obtained from nine medical
herbs, which are commonly used in traditional Korean and Chinese medicine. The nine …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
selective death of motor neurons in the central nervous system. The main cause of the …

Ethnopharmacological relevance Amyotrophic lateral sclerosis (ALS) is a lethal
neurodegenerative disorder characterized by progressive paralysis of voluntary muscles …