Autophagy is a lysosomal pathway involved in degradation of intracellular material. It
appears as an adaptation mechanism that is essential for cellular homeostasis in response …

Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disease caused by loss of upper
and lower motor neurons. The majority of ALS cases are classified as sporadic (80–90%) …

Parkinson disease (PD) is an age-related neurodegenerative disorder associated with
misfolded SNCA/α-synuclein accumulation in brain. Impaired catabolism of SNCA …

Chaperone-mediated autophagy (CMA) contributes to cellular quality control and the
cellular response to stress through the selective degradation of cytosolic proteins in …

Hutchinson Gilford progeria syndrome is a fatal disorder characterized by accelerated aging,
bone resorption and atherosclerosis, caused by a LMNA mutation which produces progerin …

Chaperone‐mediated autophagy (CMA) is a lysosomal degradation pathway that eliminates
substrate proteins through heat‐shock cognate protein 70 recognition and lysosome …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive weakness and muscle atrophy related to the loss of upper and lower motor …

Objective In acute promyelocytic leukemia (APL), normal retinoid signaling is disrupted by
an abnormal PML‐RARα fusion oncoprotein, leading to a block in cell differentiation …

Introduction Neurodegenerative diseases including amyotrophic lateral sclerosis (ALS),
Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by progressive …

Abstract Koolen-de Vries syndrome (KdVS) is a rare disorder caused by haploinsufficiency
of KAT8 regulatory NSL complex subunit 1 (KANSL1), which is characterized by intellectual …