Filter aided sample preparation–a tutorial
JR Wiśniewski - Analytica chimica acta, 2019 - Elsevier
Abstract Filter Aided Sample Preparation (FASP) is a widely used protein processing
technique in “bottom-up” proteomics. Its popularity reflects the key features of the method: its …
technique in “bottom-up” proteomics. Its popularity reflects the key features of the method: its …
Targeting peptides: the new generation of targeted drug delivery systems
Peptides can act as targeting molecules, analogously to oligonucleotide aptamers and
antibodies. They are particularly efficient in terms of production and stability in physiological …
antibodies. They are particularly efficient in terms of production and stability in physiological …
The proteome landscape of the kingdoms of life
Proteins carry out the vast majority of functions in all biological domains, but for
technological reasons their large-scale investigation has lagged behind the study of …
technological reasons their large-scale investigation has lagged behind the study of …
Toward a consensus on applying quantitative liquid chromatography‐tandem mass spectrometry proteomics in translational pharmacology research: a white paper
Quantitative translation of information on drug absorption, disposition, receptor engagement,
and drug–drug interactions from bench to bedside requires models informed by …
and drug–drug interactions from bench to bedside requires models informed by …
Quantification of proteins involved in drug metabolism and disposition in the human liver using label-free global proteomics
There is an urgent need (recognized in FDA guidance, 2018) to optimize the dose of
medicines given to patients for maximal drug efficacy and limited toxicity (precision dosing) …
medicines given to patients for maximal drug efficacy and limited toxicity (precision dosing) …
Quantitative proteomics in translational absorption, distribution, metabolism, and excretion and precision medicine
A reliable translation of in vitro and preclinical data on drug absorption, distribution,
metabolism, and excretion (ADME) to humans is important for safe and effective drug …
metabolism, and excretion (ADME) to humans is important for safe and effective drug …
Differential tissue abundance of membrane-bound drug metabolizing enzymes and transporter proteins by global proteomics
Protein abundance data of drug-metabolizing enzymes and transporters (DMETs) are useful
for scaling in vitro and animal data to humans for accurate prediction and interpretation of …
for scaling in vitro and animal data to humans for accurate prediction and interpretation of …
The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells
Proteasome machinery is a major proteostasis control system in human cells, actively
compensated upon its inhibition. To understand this compensation, we compared global …
compensated upon its inhibition. To understand this compensation, we compared global …
Proteome analysis of tissues by mass spectrometry
I Dapic, L Baljeu‐Neuman, N Uwugiaren… - Mass spectrometry …, 2019 - Wiley Online Library
Tissues and biofluids are important sources of information used for the detection of diseases
and decisions on patient therapies. There are several accepted methods for preservation of …
and decisions on patient therapies. There are several accepted methods for preservation of …
Cell‐type‐resolved proteomic analysis of the human liver
Abstract Background & Aims The human liver functions through a complex interplay
between parenchymal and non‐parenchymal cells. Mass spectrometry‐based proteomic …
between parenchymal and non‐parenchymal cells. Mass spectrometry‐based proteomic …