From purines to purinergic signalling: molecular functions and human diseases
Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …
NMR as a “gold standard” method in drug design and discovery
Studying disease models at the molecular level is vital for drug development in order to
improve treatment and prevent a wide range of human pathologies. Microbial infections are …
improve treatment and prevent a wide range of human pathologies. Microbial infections are …
[HTML][HTML] Structures of human A1 and A2A adenosine receptors with xanthines reveal determinants of selectivity
RKY Cheng, E Segala, N Robertson, F Deflorian… - Structure, 2017 - cell.com
The adenosine A 1 and A 2A receptors belong to the purinergic family of G protein-coupled
receptors, and regulate diverse functions of the cardiovascular, respiratory, renal …
receptors, and regulate diverse functions of the cardiovascular, respiratory, renal …
Structural connection between activation microswitch and allosteric sodium site in GPCR signaling
Sodium ions are endogenous allosteric modulators of many G-protein-coupled receptors
(GPCRs). Mutation of key residues in the sodium binding motif causes a striking effect on G …
(GPCRs). Mutation of key residues in the sodium binding motif causes a striking effect on G …
The role of dietary antioxidants in type 2 diabetes and neurodegenerative disorders: An assessment of the benefit profile
Healthy diet is vital to cellular health. The human body succumbs to numerous diseases
which afflict severe economic and psychological burdens on the patient and family …
which afflict severe economic and psychological burdens on the patient and family …
[HTML][HTML] Adenosine and its receptors as therapeutic targets: an overview
S Sachdeva, M Gupta - Saudi Pharmaceutical Journal, 2013 - Elsevier
The main goal of the authors is to present an overview of adenosine and its receptors, which
are G-protein coupled receptors. The four known adenosine receptor subtypes are …
are G-protein coupled receptors. The four known adenosine receptor subtypes are …
G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders
Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …
Identifying treatment targets is challenging because the diseases are resulting from …
Human Adenosine A2A Receptor: Molecular Mechanism of Ligand Binding and Activation
B Carpenter, G Lebon - Frontiers in pharmacology, 2017 - frontiersin.org
Adenosine receptors (ARs) comprise the P1 class of purinergic receptors and belong to the
largest family of integral membrane proteins in the human genome, the G protein-coupled …
largest family of integral membrane proteins in the human genome, the G protein-coupled …
Novel targeted therapies for Parkinson's disease
T Ntetsika, PE Papathoma, I Markaki - Molecular Medicine, 2021 - Springer
Parkinson's disease (PD) is the second more common neurodegenerative disease with
increasing incidence worldwide associated to the population ageing. Despite increasing …
increasing incidence worldwide associated to the population ageing. Despite increasing …
Emerging therapies for Parkinson's disease: from bench to bedside
The prevalence of Parkinson's disease (PD) increases with age and is projected to increase
in parallel to the rising average age of the population. The disease can have significant …
in parallel to the rising average age of the population. The disease can have significant …