Quantitative phase imaging: recent advances and expanding potential in biomedicine

TL Nguyen, S Pradeep, RL Judson-Torres, J Reed… - ACS …, 2022 - ACS Publications
Quantitative phase imaging (QPI) is a label-free, wide-field microscopy approach with
significant opportunities for biomedical applications. QPI uses the natural phase shift of light …

Mechanical adaptability of tumor cells in metastasis

V Gensbittel, M Kräter, S Harlepp, I Busnelli, J Guck… - Developmental cell, 2021 - cell.com
The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will
successfully form life-threatening metastases when they undergo sequential steps along a …

Micropipette-assisted atomic force microscopy for single-cell 3D manipulations and nanomechanical measurements

Y Feng, M Li - Nanoscale, 2023 - pubs.rsc.org
Mechanical cues play a crucial role in regulating physiological and pathological processes,
and atomic force microscopy (AFM) has become an important and standard tool for …

Perspective on quantitative phase imaging to improve precision cancer medicine

Y Liu, S Uttam - Journal of biomedical optics, 2024 - spiedigitallibrary.org
Significance Quantitative phase imaging (QPI) offers a label-free approach to non-invasively
characterize cellular processes by exploiting their refractive index based intrinsic contrast …

Marangoni effect and cell spreading

I Pajic-Lijakovic, M Milivojevic - European Biophysics Journal, 2022 - Springer
Cells are very sensitive to the shear stress (SS). However, undesirable SS is generated
during physiological process such as collective cell migration (CCM) and influences the …

White blood cell detection, classification and analysis using phase imaging with computational specificity (PICS)

MJ Fanous, S He, S Sengupta, K Tangella, N Sobh… - Scientific reports, 2022 - nature.com
Abstract Treatment of blood smears with Wright's stain is one of the most helpful tools in
detecting white blood cell abnormalities. However, to diagnose leukocyte disorders, a …

Cancer-cell deep-learning classification by integrating quantitative-phase spatial and temporal fluctuations

S Ben Baruch, N Rotman-Nativ, A Baram, H Greenspan… - Cells, 2021 - mdpi.com
We present a new classification approach for live cells, integrating together the spatial and
temporal fluctuation maps and the quantitative optical thickness map of the cell, as acquired …

Dielectric Metasurface Enabled Compact, Single-Shot Digital Holography for Quantitative Phase Imaging

J Sardana, S Devinder, W Zhu, A Agrawal… - Nano Letters, 2023 - ACS Publications
Quantitative phase imaging (QPI) enables nondestructive, real-time, label-free imaging of
transparent specimens and can reveal information about their fundamental properties such …

Cancer cell viscoelasticity measurement by quantitative phase and flow stress induction

T Vicar, J Chmelik, J Navratil, R Kolar, L Chmelikova… - Biophysical …, 2022 - cell.com
Cell viscoelastic properties are affected by the cell cycle, differentiation, and pathological
processes such as malignant transformation. Therefore, evaluation of the mechanical …

Quantitative phase microscopy monitors subcellular dynamics in single cells exposed to nanosecond pulsed electric fields

ZA Steelman, ZN Coker, A Kiester… - Journal of …, 2021 - Wiley Online Library
A substantial body of literature exists to study the dynamics of single cells exposed to short
duration (< 1 μs), high peak power (~ 1 MV/m) transient electric fields. Much of this research …