Macrophages are crucial drivers of tumour-promoting inflammation. Tumour-associated
macrophages (TAMs) contribute to tumour progression at different levels: by promoting …

The macrophage is a key cell in the pro-and anti-inflammatory response including that of the
inflammatory microenvironment of malignant tumors. Much current drug development in …

Immunotherapy has shown encouraging results in various cancers, but the response rates
are relatively low due to the complex tumor immunosuppressive microenvironment (TIME) …

Epigenetic alterations play an important role in tumor progression of diffuse large B-cell
lymphoma (DLBCL). However, the biological relevance of epigenetic gene mutations on …

The observation that a subset of cancer patients show evidence for spontaneous CD8+ T
cell priming against tumor-associated antigens has generated renewed interest in the innate …

The fact that various immune cells, including macrophages, can be found in tumor tissue has
long been known. With the recent introduction of the novel concept of macrophage …

Inflammation is now a well-recognized hallmark of cancer progression. Tumor-associated
macrophages (TAMs) are one of the major inflammatory cells that infiltrate murine and …

Purpose: Programmed cell death ligand 1 (PD-L1) is an immunomodulatory molecule
expressed by antigen-presenting cells and select tumors that engages receptors on T cells …

Purpose In contrast to Hodgkin lymphoma and systemic anaplastic large-cell lymphoma,
CD30 expression of malignant lymphocytes in mycosis fungoides (MF) and Sézary …

Tumor‐associated macrophages (TAMs) play a pivotal role in tumor growth in human
malignancies. Published studies have analyzed the relationship between TAM infiltration …