Multidimensional chromatography coupled to mass spectrometry in analysing complex proteomics samples

P Horvatovich, B Hoekman… - Journal of separation …, 2010 - Wiley Online Library
Multidimensional chromatography coupled to mass spectrometry (LCn‐MS) provides more
separation power and an extended measured dynamic concentration range to analyse …

Theories to support method development in comprehensive two‐dimensional liquid chromatography–A review

F Bedani, PJ Schoenmakers… - Journal of separation …, 2012 - Wiley Online Library
On‐line comprehensive two‐dimensional liquid chromatography techniques promise to
resolve samples that current one‐dimensional liquid chromatography methods cannot …

Selective comprehensive multi-dimensional separation for resolution enhancement in high performance liquid chromatography. Part I: principles and instrumentation

SR Groskreutz, MM Swenson, LB Secor… - … of Chromatography A, 2012 - Elsevier
An approach to enhancing the resolution of select portions of conventional one-dimensional
high performance liquid chromatography (HPLC) separations was developed, which we …

Evaluation of detection sensitivity in comprehensive two-dimensional liquid chromatography separations of an active pharmaceutical ingredient and its degradants

DR Stoll, ES Talus, DC Harmes, K Zhang - Analytical and bioanalytical …, 2015 - Springer
In this paper, we describe the findings of a study aimed at assessing the detection sensitivity
of comprehensive two-dimensional high-performance liquid chromatography (LCxLC) …

Comprehensive two-dimensional temperature-responsive× reversed phase liquid chromatography for the analysis of wine phenolics

K Wicht, M Baert, M Muller, E Bandini, S Schipperges… - Talanta, 2022 - Elsevier
Phenolic compounds are an interesting class of natural products because of their proposed
contribution to health benefits of foods and beverages and as a bio-source of organic …

Improving peak capacity in fast online comprehensive two-dimensional liquid chromatography with post-first-dimension flow splitting

MR Filgueira, Y Huang, K Witt, C Castells… - Analytical …, 2011 - ACS Publications
The use of flow splitters between the two dimensions in online comprehensive two-
dimensional (2D) liquid chromatography (LC× LC) has not received very much attention, in …

Theoretical evaluation of peak capacity improvements by use of liquid chromatography combined with drift tube ion mobility-mass spectrometry

TJ Causon, S Hann - Journal of Chromatography A, 2015 - Elsevier
In the domain of liquid phase separations, the quality of separation obtainable is most
readily gauged by consideration of classical chromatographic peak capacity theory. Column …

Recent advances in on-line multidimensional liquid chromatography

H Malerod, E Lundanes, T Greibrokk - Analytical Methods, 2010 - pubs.rsc.org
Multidimensional liquid chromatography (MD LC) has, due to enhanced peak capacity
compared to one-dimensional LC, become an important analytical tool for separating …

A novel stop-flow two-dimensional liquid chromatography–mass spectrometry method for lipid analysis

S Wang, J Li, X Shi, L Qiao, X Lu, G Xu - Journal of Chromatography A, 2013 - Elsevier
A novel on-line two dimensional liquid chromatography (2D LC) based on stop-flow mode
coupled with electrospray ionization mass spectrometry (ESI–MS) method was established …

Development of a comprehensive two-dimensional liquid chromatographic mass spectrometric method for the non-targeted identification of poly-and perfluoroalkyl …

L Renai, M Del Bubba, S Samanipour, R Stafford… - Analytica Chimica …, 2022 - Elsevier
In this research, we developed an online comprehensive two-dimensional liquid
chromatographic (LC× LC) method hyphenated with high-resolution mass spectrometry …