The abnormal regulation of alternative splicing is usually accompanied by the occurrence
and development of tumors, which would produce multiple different isoforms and diversify …

The epithelial–mesenchymal transition (EMT) provides an outstanding example of cellular
plasticity during embryonic development and cancer progression. During EMT in embryonic …

RNA-binding proteins (RBPs) are key players in post-transcriptional events. The
combination of versatility of their RNA-binding domains with structural flexibility enables …

Heterogeneous nuclear ribonucleoproteins (hnRNPs) represent a large family of RNA-
binding proteins (RBPs) that contribute to multiple aspects of nucleic acid metabolism …

The recent genomic characterization of cancers has revealed recurrent somatic point
mutations and copy number changes affecting genes encoding RNA splicing factors. Initial …

Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …

RNA-binding proteins (RBPs) can regulate gene expression through post-transcriptionally
influencing all manner of RNA biology, including alternative splicing (AS), polyadenylation …

Alternative splicing allows for the expression of multiple RNA and protein isoforms from one
gene, making it a major contributor to transcriptome and proteome diversification in …

Circular RNAs (circRNAs) have emerged as key regulators of human cancers, yet their
modes of action in gastric cancer (GC) remain largely unknown. Here, we identified circURI1 …

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …