Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain

RJ Harvey, BK Yee - Nature reviews Drug discovery, 2013 - nature.com
Glycine transporters are endogenous regulators of the dual functions of glycine, which acts
as a classical inhibitory neurotransmitter at glycinergic synapses and as a modulator of …

Glycine transporters and its coupling with NMDA receptors

F Zafra, I Ibáñez, D Bartolomé-Martín, D Piniella… - Glial Amino Acid …, 2017 - Springer
Glycine plays two roles in neurotransmission. In caudal areas like the spinal cord and the
brainstem, it acts as an inhibitory neurotransmitter, but in all regions of the CNS, it also works …

Inhibition of glycine transporter 1: the yellow brick road to new schizophrenia therapy?

P Singer, S Dubroqua, BK Yee - Current pharmaceutical …, 2015 - ingentaconnect.com
While pharmacological blockade of dopamine D2 receptor can effectively suppress the
psychotic or positive symptoms of schizophrenia, there is no satisfactory medication for the …

A (H1N1) vaccination recruits T lymphocytes to the choroid plexus for the promotion of hippocampal neurogenesis and working memory in pregnant mice

F Qi, J Yang, Y Xia, Q Yuan, K Guo, J Zou… - Brain, behavior, and …, 2016 - Elsevier
We previously demonstrated that A (H1N1) influenza vaccine (AIV) promoted hippocampal
neurogenesis and working memory in pregnant mice. However, the underlying mechanism …

A conceptual and practical guide to the behavioural evaluation of animal models of the symptomatology and therapy of schizophrenia

BK Yee, P Singer - Cell and tissue research, 2013 - Springer
Schizophrenia is a chronic debilitating brain disorder characterized by a complex set of
perceptual and behavioural symptoms that severely disrupt and undermine the patient's …

Influenza A (H1N1) vaccination during early pregnancy transiently promotes hippocampal neurogenesis and working memory. Involvement of Th1/Th2 balance

Y Xia, F Qi, J Zou, Z Yao - brain research, 2014 - Elsevier
Abstract The 2009 influenza A (H1N1) pandemic led to a particularly high risk of morbidity
and mortality among pregnant women. Therefore, inactivated influenza vaccines have been …

Phenotype of mice with inducible ablation of GluA1 AMPA receptors during late adolescence: relevance for mental disorders

D Inta, MA Vogt, H Elkin, T Weber… - …, 2014 - Wiley Online Library
Adolescence is characterized by important molecular and anatomical changes with
relevance for the maturation of brain circuitry and cognitive function. This time period is of …

GlyT1 encephalopathy: Characterization of presumably disease causing GlyT1 mutations

K Hauf, L Barsch, D Bauer, R Buchert… - Neurochemistry …, 2020 - Elsevier
Glycine constitutes a major inhibitory neurotransmitter predominantly in caudal regions of
the CNS. The extracellular glycine concentration is regulated synergistically by two high …

Negative transfer effects between reference memory and working memory training in the water maze in C57BL/6 mice

LES Sponton, GJ Soria, S Dubroqua, P Singer… - Behavioural brain …, 2018 - Elsevier
The water maze is one of the most widely employed spatial learning paradigms in the
cognitive profiling of genetically modified mice. Oftentimes, tests of reference memory (RM) …

Translating the Glutamatergic Hypothesis of Schizophrenia Through Homeostatic Regulation of Brain Glycine

S Dubroqua, P Singer, BK Yee - Psychiatry and Neuroscience Update …, 2015 - Springer
No effective treatment exists for the negative symptoms and cognitive impairments of
schizophrenia. The loss of normal affective and cognitive function severely undermines a …