Mechanisms of bone development and repair

A Salhotra, HN Shah, B Levi… - Nature reviews Molecular …, 2020 - nature.com
Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Wnt signaling in development and tissue homeostasis

Z Steinhart, S Angers - Development, 2018 - journals.biologists.com
The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication
system that is important for stem cell renewal, cell proliferation and cell differentiation both …

[HTML][HTML] Wnt/β-catenin signaling, disease, and emerging therapeutic modalities

R Nusse, H Clevers - Cell, 2017 - cell.com
The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …

Romosozumab or alendronate for fracture prevention in women with osteoporosis

KG Saag, J Petersen, ML Brandi… - … England Journal of …, 2017 - Mass Medical Soc
Background Romosozumab is a monoclonal antibody that binds to and inhibits sclerostin,
increases bone formation, and decreases bone resorption. Methods We enrolled 4093 …

The regulation of bone metabolism and disorders by Wnt signaling

K Maeda, Y Kobayashi, M Koide, S Uehara… - International journal of …, 2019 - mdpi.com
Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a
cytokine involved in various biological phenomena including ontogeny, morphogenesis …

Romosozumab treatment in postmenopausal women with osteoporosis

F Cosman, DB Crittenden, JD Adachi… - … England Journal of …, 2016 - Mass Medical Soc
Background Romosozumab, a monoclonal antibody that binds sclerostin, increases bone
formation and decreases bone resorption. Methods We enrolled 7180 postmenopausal …

Drug development in the era of precision medicine

SA Dugger, A Platt, DB Goldstein - Nature reviews Drug discovery, 2018 - nature.com
For the past three decades, the use of genomics to inform drug discovery and development
pipelines has generated both excitement and scepticism. Although earlier efforts …

Bone modeling and remodeling: potential as therapeutic targets for the treatment of osteoporosis

B Langdahl, S Ferrari… - Therapeutic advances in …, 2016 - journals.sagepub.com
The adult skeleton is renewed by remodeling throughout life. Bone remodeling is a process
where osteoclasts and osteoblasts work sequentially in the same bone remodeling unit …

Role and mechanism of action of sclerostin in bone

J Delgado-Calle, AY Sato, T Bellido - Bone, 2017 - Elsevier
After discovering that lack of Sost/sclerostin expression is the cause of the high bone mass
human syndromes Van Buchem disease and sclerosteosis, extensive animal …

The role of osteoblasts in energy homeostasis

N Dirckx, MC Moorer, TL Clemens… - Nature Reviews …, 2019 - nature.com
Osteoblasts are specialized mesenchymal cells that synthesize bone matrix and coordinate
the mineralization of the skeleton. These cells work in harmony with osteoclasts, which …