In the past, conventional drug discovery strategies have been successfully employed to
develop new drugs, but the process from lead identification to clinical trials takes more than …

Computer-aided drug discovery/design methods have played a major role in the
development of therapeutically important small molecules for over three decades. These …

Several technology-based strategies have been developed to address the significance of
the two phases of drug discovery: hit identification and lead identification. Structure-based …

Aurora kinase belongs to serine/threonine kinase family which controls cell division.
Therapeutic inhibition of Aurora kinase showed great promise as probable anticancer …

Developing a novel drug is a complex, risky, expensive and time-consuming venture. It is
estimated that the conventional drug discovery process ending with a new medicine ready …

Aurora kinases control multiple events during cell cycle progression and are essential for
mitotic and meiotic bipolar spindle assembly and function. There are three Aurora kinases in …

Aurora kinases are essential for cell division and are frequently misregulated in human
cancers. Based on their potential as cancer therapeutics, a plethora of small molecule …

The Aurora kinases regulate multiple aspects of mitotic progression, and their
overexpression in diverse tumor types makes them appealing oncology targets. An intensive …

Many eukaryotic protein kinases are activated by phosphorylation on a specific conserved
residue in the regulatory activation loop, a post-translational modification thought to stabilize …

Pyrazole, as a small molecule, was discovered for higher cytotoxicity and affinity towards
Aurora-A kinase. Based on these facts, a novel pyrazole substituted at the 4 th position was …