The role of macronutrients, micronutrients and flavonoid polyphenols in the prevention and treatment of osteoporosis

M Martiniakova, M Babikova, V Mondockova, J Blahova… - Nutrients, 2022 - mdpi.com
Osteoporosis is considered an age-related disorder of the skeletal system, characterized
primarily by decreased bone mineral density (BMD), microstructural quality and an elevated …

Botanicals in postmenopausal osteoporosis

W Słupski, P Jawień, B Nowak - Nutrients, 2021 - mdpi.com
Osteoporosis is a systemic bone disease characterized by reduced bone mass and the
deterioration of bone microarchitecture leading to bone fragility and an increased risk of …

Insights and implications of sexual dimorphism in osteoporosis

YY Zhang, N Xie, XD Sun, EC Nice, YC Liou, C Huang… - Bone research, 2024 - nature.com
Osteoporosis, a metabolic bone disease characterized by low bone mineral density and
deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures …

The osteoprotective effects of kaempferol: the evidence from in vivo and in vitro studies

SK Wong, KY Chin, S Ima-Nirwana - Drug design, development …, 2019 - Taylor & Francis
Kaempferol is a dietary bioflavonoid ubiquitously found in various types of plant. It
possesses a wide range of medicinal properties suggesting its potential clinical utility that …

Therapeutic anabolic and anticatabolic benefits of natural Chinese medicines for the treatment of osteoporosis

J He, X Li, Z Wang, S Bennett, K Chen, Z Xiao… - Frontiers in …, 2019 - frontiersin.org
Osteoporosis is a bone disease characterized by increasing osseous fragility and fracture
due to the reduced bone mass and microstructural degradation. Primary pharmacological …

[HTML][HTML] Kaempferol: Paving the path for advanced treatments in aging-related diseases

MS Hussain, ASA Altamimi, M Afzal, WH Almalki… - Experimental …, 2024 - Elsevier
Aging-related diseases (ARDs) are a major global health concern, and the development of
effective therapies is urgently needed. Kaempferol, a flavonoid found in several plants, has …

“Bone-SASP” in skeletal aging

CL Fang, B Liu, M Wan - Calcified Tissue International, 2023 - Springer
Senescence is a complex cell state characterized by stable cell cycle arrest and a unique
secretory pattern known as the senescence-associated secretory phenotype (SASP). The …

Natural medicine delivery from 3D printed bone substitutes

S Bose, N Sarkar, Y Jo - Journal of Controlled Release, 2024 - Elsevier
Unmet medical needs in treating critical-size bone defects have led to the development of
numerous innovative bone tissue engineering implants. Although additive manufacturing …

Kaempferol attenuates wear particle-induced inflammatory osteolysis via JNK and p38-MAPK signaling pathways

X Yu, Q Wu, Z Ren, B Chen, D Wang, T Yuan… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Wear particle-induced inflammatory osteoclast activation
is a master contributor to periprosthetic osteolysis, which can cause pathological bone loss …

Kaempferol promotes bone formation in part via the mTOR signaling pathway

J Zhao, J Wu, B Xu, Z Yuan… - Molecular …, 2019 - spandidos-publications.com
Previous research indicates that kaempferol (Kae) promotes osteogenesis, but its underlying
mechanism of action remains unclear. The present study hypothesized that the osteogenic …